Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
MY TRIALS
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Register a trial
The ANZCTR website will be unavailable from 1pm until 3pm (AEDT) on Wednesday the 30th of October for website maintenance. Please be sure to log out of the system in order to avoid any loss of data.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT02525939
Registration number
NCT02525939
Ethics application status
Date submitted
13/08/2015
Date registered
18/08/2015
Titles & IDs
Public title
Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
Query!
Scientific title
A Phase III, Double-blind, Randomized Placebo-controlled Study to Evaluate the Effects of Dalcetrapib on Cardiovascular (CV) Risk in a Genetically Defined Population With a Recent Acute Coronary Syndrome (ACS): The Dal-GenE Trial
Query!
Secondary ID [1]
0
0
DAL-301
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
dal-GenE
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome
0
0
Query!
Condition category
Condition code
Cardiovascular
0
0
0
0
Query!
Coronary heart disease
Query!
Other
0
0
0
0
Query!
Research that is not of generic health relevance and not applicable to specific health categories listed above
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - dalcetrapib
Treatment: Drugs - Placebo
Active comparator: Dalcetrapib - Participants received dalcetrapib 600 mg (two 300 mg tablets) orally once daily.
dalcetrapib: Cholesterol Ester Transfer Protein inhibitor, 300 mg tablets
Placebo comparator: Placebo - Participants received dalcetrapib placebo tablets matching dalcetrapib orally once daily.
Placebo: dalcetrapib matching placebo tablets
Treatment: Drugs: dalcetrapib
Cholesterol Ester Transfer Protein inhibitor
Treatment: Drugs: Placebo
matching placebo tablets
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
Composite of Cardiovascular Death, Resuscitated Cardiac Arrest, Non-Fatal Myocardial Infarction, and Non-Fatal Stroke
Query!
Assessment method [1]
0
0
All efficacy endpoints were adjudicated by an independent clinical endpoint committee (CEC). The primary efficacy endpoint was the time from randomization to the first occurrence of any component of the composite endpoint, which included death from cardiovascular causes, resuscitated cardiac arrest, non-fatal myocardial infarction, or non-fatal stroke, as positively adjudicated by the CEC.
Query!
Timepoint [1]
0
0
From randomization to the first occurrence of any component of the composite primary endpoint (median duration of follow-up was 39.9 months)
Query!
Secondary outcome [1]
0
0
Composite Endpoint of Cardiovascular Death, Resuscitated Cardiac Arrest, Non-Fatal Myocardial Infarction, Non-Fatal Stroke, Hospitalization for ACS (With Electrocardiogram Abnormalities) or Unanticipated Coronary Revascularization
Query!
Assessment method [1]
0
0
All efficacy endpoints were adjudicated by an independent clinical endpoint committee (CEC). The primary efficacy endpoint was the time from randomization to the first occurrence of any component of the composite endpoint, which included death from cardiovascular causes, resuscitated cardiac arrest, non-fatal myocardial infarction, non-fatal stroke, hospitalization for acute coronary syndrome (with electrocardiogram abnormalities) or unanticipated coronary revascularization, as positively adjudicated by the CEC.
Query!
Timepoint [1]
0
0
From randomization to the first occurrence of any component of the composite secondary endpoint (median duration of follow-up was 39.9 months)
Query!
Secondary outcome [2]
0
0
Composite Endpoint of Cardiovascular Death, Resuscitated Cardiac Arrest, Non-Fatal Myocardial Infarction, Non-Fatal Stroke or Hospitalization for New or Worsening Heart Failure
Query!
Assessment method [2]
0
0
All efficacy endpoints were adjudicated by an independent clinical endpoint committee (CEC). The secondary efficacy endpoint was the time from randomization to the first occurrence of any component of the composite secondary endpoint, which included death from cardiovascular causes, cardiovascular death, resuscitated cardiac arrest, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for new or worsening heart failure, as positively adjudicated by the CEC.
Query!
Timepoint [2]
0
0
From randomization to the first occurrence of any component of the composite secondary endpoint (median duration of follow-up was 39.9 months)
Query!
Eligibility
Key inclusion criteria
* Subjects with the appropriate genetic background and recently hospitalized for ACS (between 4 and 12 weeks following the index event), will be enrolled in this trial.
* AA genotype at variant gene as determined by Genotype Assay testing, conducted at a designated investigational testing site (ITS)
* Clinically stable, ie, free of ischemic symptoms at rest or with minimal exertion for at least 1 week prior to randomization
* Prior to randomization, subject must have evidence of guidelines-based management of LDL-C, at a minimum to include medical and dietary treatment to a target level of LDL-C <100 mg/dl (<2.6 mmol/L).
Query!
Minimum age
45
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Females who are pregnant (negative pregnancy test required for all women of child-bearing potential at Visit 2, Day 0) or breast-feeding
* Women of childbearing potential (women who are not surgically sterile or postmenopausal defined as amenorrhea for >12 months) who are not using at least one method of contraception*
* New York Heart Association (NYHA) Class III or IV heart failure
* Last known hemoglobin <10 g/dL
* Index ACS event presumed due to uncontrolled hypertension
(*) Varies by region
Query!
Study design
Purpose of the study
Treatment
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Blinded (masking used)
Query!
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Completed
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
1/04/2016
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
Query!
Actual
1/10/2021
Query!
Sample size
Target
Query!
Accrual to date
Query!
Final
6147
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,TAS,VIC,WA
Query!
Recruitment hospital [1]
0
0
Research Site - Bruce
Query!
Recruitment hospital [2]
0
0
Research Site - Gosford
Query!
Recruitment hospital [3]
0
0
Research Site - Liverpool
Query!
Recruitment hospital [4]
0
0
Research Site - Saint Leonards
Query!
Recruitment hospital [5]
0
0
Research Site - Cairns
Query!
Recruitment hospital [6]
0
0
Research Site - Chermside
Query!
Recruitment hospital [7]
0
0
Research Site - Douglas
Query!
Recruitment hospital [8]
0
0
Research Site - Herston
Query!
Recruitment hospital [9]
0
0
Research Site - Milton
Query!
Recruitment hospital [10]
0
0
Research Site - Redcliffe
Query!
Recruitment hospital [11]
0
0
Research Site - Woolloongabba
Query!
Recruitment hospital [12]
0
0
Research Site - Bedford Park
Query!
Recruitment hospital [13]
0
0
Research Site - Elizabeth Vale
Query!
Recruitment hospital [14]
0
0
Research Site - Woodville South
Query!
Recruitment hospital [15]
0
0
Research Site - Hobart
Query!
Recruitment hospital [16]
0
0
Research Site - Epping
Query!
Recruitment hospital [17]
0
0
Research Site - Geelong
Query!
Recruitment hospital [18]
0
0
Research Site - Melbourne
Query!
Recruitment hospital [19]
0
0
Research Site - Joondalup
Query!
Recruitment hospital [20]
0
0
Research Site - Murdoch
Query!
Recruitment hospital [21]
0
0
Research Site - Nedlands
Query!
Recruitment hospital [22]
0
0
Research Site - Perth
Query!
Recruitment postcode(s) [1]
0
0
- Bruce
Query!
Recruitment postcode(s) [2]
0
0
- Gosford
Query!
Recruitment postcode(s) [3]
0
0
- Liverpool
Query!
Recruitment postcode(s) [4]
0
0
- Saint Leonards
Query!
Recruitment postcode(s) [5]
0
0
- Cairns
Query!
Recruitment postcode(s) [6]
0
0
- Chermside
Query!
Recruitment postcode(s) [7]
0
0
- Douglas
Query!
Recruitment postcode(s) [8]
0
0
- Herston
Query!
Recruitment postcode(s) [9]
0
0
- Milton
Query!
Recruitment postcode(s) [10]
0
0
- Redcliffe
Query!
Recruitment postcode(s) [11]
0
0
- Woolloongabba
Query!
Recruitment postcode(s) [12]
0
0
- Bedford Park
Query!
Recruitment postcode(s) [13]
0
0
- Elizabeth Vale
Query!
Recruitment postcode(s) [14]
0
0
- Woodville South
Query!
Recruitment postcode(s) [15]
0
0
- Hobart
Query!
Recruitment postcode(s) [16]
0
0
- Epping
Query!
Recruitment postcode(s) [17]
0
0
- Geelong
Query!
Recruitment postcode(s) [18]
0
0
- Melbourne
Query!
Recruitment postcode(s) [19]
0
0
- Joondalup
Query!
Recruitment postcode(s) [20]
0
0
- Murdoch
Query!
Recruitment postcode(s) [21]
0
0
- Nedlands
Query!
Recruitment postcode(s) [22]
0
0
- Perth
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Alabama
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
Arizona
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
Arkansas
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
California
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Colorado
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Connecticut
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
District of Columbia
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Florida
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Georgia
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
Illinois
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
Indiana
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Iowa
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
Kansas
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Kentucky
Query!
Country [15]
0
0
United States of America
Query!
State/province [15]
0
0
Louisiana
Query!
Country [16]
0
0
United States of America
Query!
State/province [16]
0
0
Maine
Query!
Country [17]
0
0
United States of America
Query!
State/province [17]
0
0
Maryland
Query!
Country [18]
0
0
United States of America
Query!
State/province [18]
0
0
Massachusetts
Query!
Country [19]
0
0
United States of America
Query!
State/province [19]
0
0
Michigan
Query!
Country [20]
0
0
United States of America
Query!
State/province [20]
0
0
Minnesota
Query!
Country [21]
0
0
United States of America
Query!
State/province [21]
0
0
Missouri
Query!
Country [22]
0
0
United States of America
Query!
State/province [22]
0
0
Montana
Query!
Country [23]
0
0
United States of America
Query!
State/province [23]
0
0
Nebraska
Query!
Country [24]
0
0
United States of America
Query!
State/province [24]
0
0
Nevada
Query!
Country [25]
0
0
United States of America
Query!
State/province [25]
0
0
New Jersey
Query!
Country [26]
0
0
United States of America
Query!
State/province [26]
0
0
New Mexico
Query!
Country [27]
0
0
United States of America
Query!
State/province [27]
0
0
New York
Query!
Country [28]
0
0
United States of America
Query!
State/province [28]
0
0
North Carolina
Query!
Country [29]
0
0
United States of America
Query!
State/province [29]
0
0
North Dakota
Query!
Country [30]
0
0
United States of America
Query!
State/province [30]
0
0
Ohio
Query!
Country [31]
0
0
United States of America
Query!
State/province [31]
0
0
Oklahoma
Query!
Country [32]
0
0
United States of America
Query!
State/province [32]
0
0
Pennsylvania
Query!
Country [33]
0
0
United States of America
Query!
State/province [33]
0
0
Rhode Island
Query!
Country [34]
0
0
United States of America
Query!
State/province [34]
0
0
South Carolina
Query!
Country [35]
0
0
United States of America
Query!
State/province [35]
0
0
South Dakota
Query!
Country [36]
0
0
United States of America
Query!
State/province [36]
0
0
Tennessee
Query!
Country [37]
0
0
United States of America
Query!
State/province [37]
0
0
Texas
Query!
Country [38]
0
0
United States of America
Query!
State/province [38]
0
0
Utah
Query!
Country [39]
0
0
United States of America
Query!
State/province [39]
0
0
Virginia
Query!
Country [40]
0
0
United States of America
Query!
State/province [40]
0
0
Washington
Query!
Country [41]
0
0
United States of America
Query!
State/province [41]
0
0
Wisconsin
Query!
Country [42]
0
0
Argentina
Query!
State/province [42]
0
0
Bahía Blanca
Query!
Country [43]
0
0
Argentina
Query!
State/province [43]
0
0
Ciudad Autonoma de Buenos Aires
Query!
Country [44]
0
0
Argentina
Query!
State/province [44]
0
0
Cordoba
Query!
Country [45]
0
0
Argentina
Query!
State/province [45]
0
0
Coronel Suarez
Query!
Country [46]
0
0
Argentina
Query!
State/province [46]
0
0
Corrientes
Query!
Country [47]
0
0
Argentina
Query!
State/province [47]
0
0
Esperanza
Query!
Country [48]
0
0
Argentina
Query!
State/province [48]
0
0
Junin
Query!
Country [49]
0
0
Argentina
Query!
State/province [49]
0
0
La Plata
Query!
Country [50]
0
0
Argentina
Query!
State/province [50]
0
0
Mar del Plata
Query!
Country [51]
0
0
Argentina
Query!
State/province [51]
0
0
Mendoza
Query!
Country [52]
0
0
Argentina
Query!
State/province [52]
0
0
Moron
Query!
Country [53]
0
0
Argentina
Query!
State/province [53]
0
0
Quilmes
Query!
Country [54]
0
0
Argentina
Query!
State/province [54]
0
0
Rosario
Query!
Country [55]
0
0
Argentina
Query!
State/province [55]
0
0
San Juan
Query!
Country [56]
0
0
Argentina
Query!
State/province [56]
0
0
San Luis
Query!
Country [57]
0
0
Argentina
Query!
State/province [57]
0
0
San Martin
Query!
Country [58]
0
0
Argentina
Query!
State/province [58]
0
0
San Miguel de Tucuman
Query!
Country [59]
0
0
Argentina
Query!
State/province [59]
0
0
San Nicolas
Query!
Country [60]
0
0
Argentina
Query!
State/province [60]
0
0
Santa Fe
Query!
Country [61]
0
0
Argentina
Query!
State/province [61]
0
0
Santa Rosa
Query!
Country [62]
0
0
Argentina
Query!
State/province [62]
0
0
Tucuman
Query!
Country [63]
0
0
Argentina
Query!
State/province [63]
0
0
Venado Tuerto
Query!
Country [64]
0
0
Argentina
Query!
State/province [64]
0
0
Vicente Lopez
Query!
Country [65]
0
0
Argentina
Query!
State/province [65]
0
0
Villa Allende
Query!
Country [66]
0
0
Argentina
Query!
State/province [66]
0
0
Villa Maria
Query!
Country [67]
0
0
Austria
Query!
State/province [67]
0
0
Braunau Am Inn
Query!
Country [68]
0
0
Austria
Query!
State/province [68]
0
0
Feldkirch
Query!
Country [69]
0
0
Austria
Query!
State/province [69]
0
0
Krems
Query!
Country [70]
0
0
Austria
Query!
State/province [70]
0
0
Linz
Query!
Country [71]
0
0
Austria
Query!
State/province [71]
0
0
Vienna
Query!
Country [72]
0
0
Austria
Query!
State/province [72]
0
0
Wiener Neustadt
Query!
Country [73]
0
0
Austria
Query!
State/province [73]
0
0
Wien
Query!
Country [74]
0
0
Belgium
Query!
State/province [74]
0
0
Aalst
Query!
Country [75]
0
0
Belgium
Query!
State/province [75]
0
0
Bonheiden
Query!
Country [76]
0
0
Belgium
Query!
State/province [76]
0
0
Brussels
Query!
Country [77]
0
0
Belgium
Query!
State/province [77]
0
0
Genk
Query!
Country [78]
0
0
Belgium
Query!
State/province [78]
0
0
Liege
Query!
Country [79]
0
0
Belgium
Query!
State/province [79]
0
0
Maaseik
Query!
Country [80]
0
0
Belgium
Query!
State/province [80]
0
0
Mechelen
Query!
Country [81]
0
0
Belgium
Query!
State/province [81]
0
0
Ottignies
Query!
Country [82]
0
0
Belgium
Query!
State/province [82]
0
0
Sint-Niklaas
Query!
Country [83]
0
0
Brazil
Query!
State/province [83]
0
0
Belo Horizonte
Query!
Country [84]
0
0
Brazil
Query!
State/province [84]
0
0
Blumenau
Query!
Country [85]
0
0
Brazil
Query!
State/province [85]
0
0
Brasilia
Query!
Country [86]
0
0
Brazil
Query!
State/province [86]
0
0
Campina Grande do Sul
Query!
Country [87]
0
0
Brazil
Query!
State/province [87]
0
0
Campinas
Query!
Country [88]
0
0
Brazil
Query!
State/province [88]
0
0
Campo Grande
Query!
Country [89]
0
0
Brazil
Query!
State/province [89]
0
0
Curitiba
Query!
Country [90]
0
0
Brazil
Query!
State/province [90]
0
0
Fortaleza
Query!
Country [91]
0
0
Brazil
Query!
State/province [91]
0
0
Goiania
Query!
Country [92]
0
0
Brazil
Query!
State/province [92]
0
0
Marilia
Query!
Country [93]
0
0
Brazil
Query!
State/province [93]
0
0
Maringa
Query!
Country [94]
0
0
Brazil
Query!
State/province [94]
0
0
Natal
Query!
Country [95]
0
0
Brazil
Query!
State/province [95]
0
0
Porto Alegre
Query!
Country [96]
0
0
Brazil
Query!
State/province [96]
0
0
Recife
Query!
Country [97]
0
0
Brazil
Query!
State/province [97]
0
0
Ribeirao Preto
Query!
Country [98]
0
0
Brazil
Query!
State/province [98]
0
0
Salvador
Query!
Country [99]
0
0
Brazil
Query!
State/province [99]
0
0
Santo André
Query!
Country [100]
0
0
Brazil
Query!
State/province [100]
0
0
Sao Jose do Rio Preto
Query!
Country [101]
0
0
Brazil
Query!
State/province [101]
0
0
Sao Paulo
Query!
Country [102]
0
0
Brazil
Query!
State/province [102]
0
0
Uberlandia
Query!
Country [103]
0
0
Brazil
Query!
State/province [103]
0
0
Vitoria
Query!
Country [104]
0
0
Bulgaria
Query!
State/province [104]
0
0
Blagoevgrad
Query!
Country [105]
0
0
Bulgaria
Query!
State/province [105]
0
0
Dimitrovgrad
Query!
Country [106]
0
0
Bulgaria
Query!
State/province [106]
0
0
Haskovo
Query!
Country [107]
0
0
Bulgaria
Query!
State/province [107]
0
0
Pazardzhik
Query!
Country [108]
0
0
Bulgaria
Query!
State/province [108]
0
0
Pernik
Query!
Country [109]
0
0
Bulgaria
Query!
State/province [109]
0
0
Pleven
Query!
Country [110]
0
0
Bulgaria
Query!
State/province [110]
0
0
Plovdiv
Query!
Country [111]
0
0
Bulgaria
Query!
State/province [111]
0
0
Sandanski
Query!
Country [112]
0
0
Bulgaria
Query!
State/province [112]
0
0
Sofia
Query!
Country [113]
0
0
Canada
Query!
State/province [113]
0
0
Alberta
Query!
Country [114]
0
0
Canada
Query!
State/province [114]
0
0
British Columbia
Query!
Country [115]
0
0
Canada
Query!
State/province [115]
0
0
Manitoba
Query!
Country [116]
0
0
Canada
Query!
State/province [116]
0
0
New Brunswick
Query!
Country [117]
0
0
Canada
Query!
State/province [117]
0
0
Newfoundland and Labrador
Query!
Country [118]
0
0
Canada
Query!
State/province [118]
0
0
Nova Scotia
Query!
Country [119]
0
0
Canada
Query!
State/province [119]
0
0
Ontario
Query!
Country [120]
0
0
Canada
Query!
State/province [120]
0
0
Quebec
Query!
Country [121]
0
0
Canada
Query!
State/province [121]
0
0
Québec
Query!
Country [122]
0
0
Chile
Query!
State/province [122]
0
0
Santiago
Query!
Country [123]
0
0
Chile
Query!
State/province [123]
0
0
Temuco
Query!
Country [124]
0
0
Chile
Query!
State/province [124]
0
0
Vina del Mar
Query!
Country [125]
0
0
Czechia
Query!
State/province [125]
0
0
Bilina
Query!
Country [126]
0
0
Czechia
Query!
State/province [126]
0
0
Brno
Query!
Country [127]
0
0
Czechia
Query!
State/province [127]
0
0
Hradec Kralove
Query!
Country [128]
0
0
Czechia
Query!
State/province [128]
0
0
Jihlava
Query!
Country [129]
0
0
Czechia
Query!
State/province [129]
0
0
Kladno
Query!
Country [130]
0
0
Czechia
Query!
State/province [130]
0
0
Kromeriz
Query!
Country [131]
0
0
Czechia
Query!
State/province [131]
0
0
Liberec
Query!
Country [132]
0
0
Czechia
Query!
State/province [132]
0
0
Nachod
Query!
Country [133]
0
0
Czechia
Query!
State/province [133]
0
0
Pisek
Query!
Country [134]
0
0
Czechia
Query!
State/province [134]
0
0
Plzen
Query!
Country [135]
0
0
Czechia
Query!
State/province [135]
0
0
Prague 2
Query!
Country [136]
0
0
Czechia
Query!
State/province [136]
0
0
Prague 5
Query!
Country [137]
0
0
Czechia
Query!
State/province [137]
0
0
Prague 6
Query!
Country [138]
0
0
Czechia
Query!
State/province [138]
0
0
Prague
Query!
Country [139]
0
0
Czechia
Query!
State/province [139]
0
0
Slany
Query!
Country [140]
0
0
Czechia
Query!
State/province [140]
0
0
Trutnov
Query!
Country [141]
0
0
Czechia
Query!
State/province [141]
0
0
Zlin
Query!
Country [142]
0
0
Denmark
Query!
State/province [142]
0
0
Aalborg
Query!
Country [143]
0
0
Denmark
Query!
State/province [143]
0
0
Frederiksberg
Query!
Country [144]
0
0
Denmark
Query!
State/province [144]
0
0
Glostrup
Query!
Country [145]
0
0
Denmark
Query!
State/province [145]
0
0
Hellerup
Query!
Country [146]
0
0
Denmark
Query!
State/province [146]
0
0
Herning
Query!
Country [147]
0
0
Denmark
Query!
State/province [147]
0
0
Hillerod
Query!
Country [148]
0
0
Denmark
Query!
State/province [148]
0
0
Kobenhavn
Query!
Country [149]
0
0
Denmark
Query!
State/province [149]
0
0
Naestved
Query!
Country [150]
0
0
Denmark
Query!
State/province [150]
0
0
Silkeborg
Query!
Country [151]
0
0
Finland
Query!
State/province [151]
0
0
Jyvaskyla
Query!
Country [152]
0
0
Finland
Query!
State/province [152]
0
0
Oulu
Query!
Country [153]
0
0
Finland
Query!
State/province [153]
0
0
Pori
Query!
Country [154]
0
0
Finland
Query!
State/province [154]
0
0
Turku
Query!
Country [155]
0
0
France
Query!
State/province [155]
0
0
Besancon
Query!
Country [156]
0
0
France
Query!
State/province [156]
0
0
Bron
Query!
Country [157]
0
0
France
Query!
State/province [157]
0
0
Clermont-Ferrand
Query!
Country [158]
0
0
France
Query!
State/province [158]
0
0
Corbeil-Essonnes
Query!
Country [159]
0
0
France
Query!
State/province [159]
0
0
Dijon
Query!
Country [160]
0
0
France
Query!
State/province [160]
0
0
Limoges
Query!
Country [161]
0
0
France
Query!
State/province [161]
0
0
Lyon
Query!
Country [162]
0
0
France
Query!
State/province [162]
0
0
Montpellier
Query!
Country [163]
0
0
France
Query!
State/province [163]
0
0
Paris
Query!
Country [164]
0
0
France
Query!
State/province [164]
0
0
Pessac
Query!
Country [165]
0
0
France
Query!
State/province [165]
0
0
Poitiers
Query!
Country [166]
0
0
France
Query!
State/province [166]
0
0
Toulouse
Query!
Country [167]
0
0
France
Query!
State/province [167]
0
0
Tourcoing
Query!
Country [168]
0
0
France
Query!
State/province [168]
0
0
Valenciennes
Query!
Country [169]
0
0
Germany
Query!
State/province [169]
0
0
Aachen
Query!
Country [170]
0
0
Germany
Query!
State/province [170]
0
0
Berlin
Query!
Country [171]
0
0
Germany
Query!
State/province [171]
0
0
Bochum
Query!
Country [172]
0
0
Germany
Query!
State/province [172]
0
0
Bremen
Query!
Country [173]
0
0
Germany
Query!
State/province [173]
0
0
Chemnitz
Query!
Country [174]
0
0
Germany
Query!
State/province [174]
0
0
Coburg
Query!
Country [175]
0
0
Germany
Query!
State/province [175]
0
0
Dresden
Query!
Country [176]
0
0
Germany
Query!
State/province [176]
0
0
Erfurt
Query!
Country [177]
0
0
Germany
Query!
State/province [177]
0
0
Fuerth
Query!
Country [178]
0
0
Germany
Query!
State/province [178]
0
0
Heidelberg
Query!
Country [179]
0
0
Germany
Query!
State/province [179]
0
0
Leipzig
Query!
Country [180]
0
0
Germany
Query!
State/province [180]
0
0
Mainz
Query!
Country [181]
0
0
Germany
Query!
State/province [181]
0
0
Monchengladbach
Query!
Country [182]
0
0
Germany
Query!
State/province [182]
0
0
Munich
Query!
Country [183]
0
0
Hungary
Query!
State/province [183]
0
0
Baja
Query!
Country [184]
0
0
Hungary
Query!
State/province [184]
0
0
Balatonfured
Query!
Country [185]
0
0
Hungary
Query!
State/province [185]
0
0
Budapest
Query!
Country [186]
0
0
Hungary
Query!
State/province [186]
0
0
Eger
Query!
Country [187]
0
0
Hungary
Query!
State/province [187]
0
0
Gyula
Query!
Country [188]
0
0
Hungary
Query!
State/province [188]
0
0
Hatvan
Query!
Country [189]
0
0
Hungary
Query!
State/province [189]
0
0
Kecskemet
Query!
Country [190]
0
0
Hungary
Query!
State/province [190]
0
0
Miskolc
Query!
Country [191]
0
0
Hungary
Query!
State/province [191]
0
0
Nyiregyhaza
Query!
Country [192]
0
0
Hungary
Query!
State/province [192]
0
0
Pecs
Query!
Country [193]
0
0
Hungary
Query!
State/province [193]
0
0
Szekesfehervar
Query!
Country [194]
0
0
Hungary
Query!
State/province [194]
0
0
Szombathely
Query!
Country [195]
0
0
Hungary
Query!
State/province [195]
0
0
Zalaegerszeg
Query!
Country [196]
0
0
Israel
Query!
State/province [196]
0
0
Afula
Query!
Country [197]
0
0
Israel
Query!
State/province [197]
0
0
Ashkelon
Query!
Country [198]
0
0
Israel
Query!
State/province [198]
0
0
Beer Sheva
Query!
Country [199]
0
0
Israel
Query!
State/province [199]
0
0
Bnei Brak
Query!
Country [200]
0
0
Israel
Query!
State/province [200]
0
0
Haifa
Query!
Country [201]
0
0
Israel
Query!
State/province [201]
0
0
Holon
Query!
Country [202]
0
0
Israel
Query!
State/province [202]
0
0
Jerusalem
Query!
Country [203]
0
0
Israel
Query!
State/province [203]
0
0
Kfar Saba
Query!
Country [204]
0
0
Israel
Query!
State/province [204]
0
0
Nahariya
Query!
Country [205]
0
0
Israel
Query!
State/province [205]
0
0
Nazareth
Query!
Country [206]
0
0
Israel
Query!
State/province [206]
0
0
Petach-Tikva
Query!
Country [207]
0
0
Israel
Query!
State/province [207]
0
0
Poriyya 'Illit
Query!
Country [208]
0
0
Israel
Query!
State/province [208]
0
0
Rehovot
Query!
Country [209]
0
0
Israel
Query!
State/province [209]
0
0
Safed
Query!
Country [210]
0
0
Israel
Query!
State/province [210]
0
0
Tel Aviv
Query!
Country [211]
0
0
Israel
Query!
State/province [211]
0
0
Tel Hashomer
Query!
Country [212]
0
0
Israel
Query!
State/province [212]
0
0
Zerifin
Query!
Country [213]
0
0
Italy
Query!
State/province [213]
0
0
Ancona
Query!
Country [214]
0
0
Italy
Query!
State/province [214]
0
0
Ascoli Piceno
Query!
Country [215]
0
0
Italy
Query!
State/province [215]
0
0
Cagliari
Query!
Country [216]
0
0
Italy
Query!
State/province [216]
0
0
Casarano
Query!
Country [217]
0
0
Italy
Query!
State/province [217]
0
0
Cortona
Query!
Country [218]
0
0
Italy
Query!
State/province [218]
0
0
Empoli
Query!
Country [219]
0
0
Italy
Query!
State/province [219]
0
0
Firenze
Query!
Country [220]
0
0
Italy
Query!
State/province [220]
0
0
Foggia
Query!
Country [221]
0
0
Italy
Query!
State/province [221]
0
0
Giugliano in Campania
Query!
Country [222]
0
0
Italy
Query!
State/province [222]
0
0
Gubbio
Query!
Country [223]
0
0
Italy
Query!
State/province [223]
0
0
Milano
Query!
Country [224]
0
0
Italy
Query!
State/province [224]
0
0
Napoli
Query!
Country [225]
0
0
Italy
Query!
State/province [225]
0
0
Novara
Query!
Country [226]
0
0
Italy
Query!
State/province [226]
0
0
Roma
Query!
Country [227]
0
0
Italy
Query!
State/province [227]
0
0
Rozzano
Query!
Country [228]
0
0
Italy
Query!
State/province [228]
0
0
Sanremo
Query!
Country [229]
0
0
Italy
Query!
State/province [229]
0
0
Saronno
Query!
Country [230]
0
0
Italy
Query!
State/province [230]
0
0
Scorrano
Query!
Country [231]
0
0
Italy
Query!
State/province [231]
0
0
Seriate
Query!
Country [232]
0
0
Italy
Query!
State/province [232]
0
0
Torino
Query!
Country [233]
0
0
Italy
Query!
State/province [233]
0
0
Treviglio
Query!
Country [234]
0
0
Netherlands
Query!
State/province [234]
0
0
's-Hertogenbosch
Query!
Country [235]
0
0
Netherlands
Query!
State/province [235]
0
0
Amsterdam
Query!
Country [236]
0
0
Netherlands
Query!
State/province [236]
0
0
Arnhem
Query!
Country [237]
0
0
Netherlands
Query!
State/province [237]
0
0
Capelle Aan Den IJssel
Query!
Country [238]
0
0
Netherlands
Query!
State/province [238]
0
0
Den Haag
Query!
Country [239]
0
0
Netherlands
Query!
State/province [239]
0
0
Deventer
Query!
Country [240]
0
0
Netherlands
Query!
State/province [240]
0
0
Doetinchem
Query!
Country [241]
0
0
Netherlands
Query!
State/province [241]
0
0
Ede
Query!
Country [242]
0
0
Netherlands
Query!
State/province [242]
0
0
Goes
Query!
Country [243]
0
0
Netherlands
Query!
State/province [243]
0
0
Gouda
Query!
Country [244]
0
0
Netherlands
Query!
State/province [244]
0
0
Hoogeveen
Query!
Country [245]
0
0
Netherlands
Query!
State/province [245]
0
0
Hoorn
Query!
Country [246]
0
0
Netherlands
Query!
State/province [246]
0
0
Leeuwarden
Query!
Country [247]
0
0
Netherlands
Query!
State/province [247]
0
0
Leiden
Query!
Country [248]
0
0
Netherlands
Query!
State/province [248]
0
0
Rotterdam
Query!
Country [249]
0
0
Netherlands
Query!
State/province [249]
0
0
Schiedam
Query!
Country [250]
0
0
Netherlands
Query!
State/province [250]
0
0
Sneek
Query!
Country [251]
0
0
Netherlands
Query!
State/province [251]
0
0
Tiel
Query!
Country [252]
0
0
Netherlands
Query!
State/province [252]
0
0
Tilburg
Query!
Country [253]
0
0
Netherlands
Query!
State/province [253]
0
0
Uden
Query!
Country [254]
0
0
Netherlands
Query!
State/province [254]
0
0
Veldhoven
Query!
Country [255]
0
0
Netherlands
Query!
State/province [255]
0
0
Venlo
Query!
Country [256]
0
0
Netherlands
Query!
State/province [256]
0
0
Zaandam
Query!
Country [257]
0
0
Netherlands
Query!
State/province [257]
0
0
Zutphen
Query!
Country [258]
0
0
New Zealand
Query!
State/province [258]
0
0
Christchurch
Query!
Country [259]
0
0
New Zealand
Query!
State/province [259]
0
0
Dunedin
Query!
Country [260]
0
0
New Zealand
Query!
State/province [260]
0
0
Grafton
Query!
Country [261]
0
0
New Zealand
Query!
State/province [261]
0
0
Hamilton
Query!
Country [262]
0
0
New Zealand
Query!
State/province [262]
0
0
Hastings
Query!
Country [263]
0
0
New Zealand
Query!
State/province [263]
0
0
Lower Hutt
Query!
Country [264]
0
0
New Zealand
Query!
State/province [264]
0
0
Nelson
Query!
Country [265]
0
0
New Zealand
Query!
State/province [265]
0
0
New Plymouth
Query!
Country [266]
0
0
New Zealand
Query!
State/province [266]
0
0
Rotorua
Query!
Country [267]
0
0
New Zealand
Query!
State/province [267]
0
0
Takapuna
Query!
Country [268]
0
0
New Zealand
Query!
State/province [268]
0
0
Wellington
Query!
Country [269]
0
0
Poland
Query!
State/province [269]
0
0
Bydgoszcz
Query!
Country [270]
0
0
Poland
Query!
State/province [270]
0
0
Elblag
Query!
Country [271]
0
0
Poland
Query!
State/province [271]
0
0
Gdynia
Query!
Country [272]
0
0
Poland
Query!
State/province [272]
0
0
Kielce
Query!
Country [273]
0
0
Poland
Query!
State/province [273]
0
0
Krakow
Query!
Country [274]
0
0
Poland
Query!
State/province [274]
0
0
Lodz
Query!
Country [275]
0
0
Poland
Query!
State/province [275]
0
0
Mragowo
Query!
Country [276]
0
0
Poland
Query!
State/province [276]
0
0
Olawa
Query!
Country [277]
0
0
Poland
Query!
State/province [277]
0
0
Oswiecim
Query!
Country [278]
0
0
Poland
Query!
State/province [278]
0
0
Plock
Query!
Country [279]
0
0
Poland
Query!
State/province [279]
0
0
Poznan
Query!
Country [280]
0
0
Poland
Query!
State/province [280]
0
0
Ruda Slaska
Query!
Country [281]
0
0
Poland
Query!
State/province [281]
0
0
Rzeszow
Query!
Country [282]
0
0
Poland
Query!
State/province [282]
0
0
Sopot
Query!
Country [283]
0
0
Poland
Query!
State/province [283]
0
0
Sroda Wielkopolska
Query!
Country [284]
0
0
Poland
Query!
State/province [284]
0
0
Szczecin
Query!
Country [285]
0
0
Poland
Query!
State/province [285]
0
0
Torun
Query!
Country [286]
0
0
Poland
Query!
State/province [286]
0
0
Wroclaw
Query!
Country [287]
0
0
Poland
Query!
State/province [287]
0
0
Zabrze
Query!
Country [288]
0
0
Poland
Query!
State/province [288]
0
0
Zamosc
Query!
Country [289]
0
0
Portugal
Query!
State/province [289]
0
0
Almada
Query!
Country [290]
0
0
Portugal
Query!
State/province [290]
0
0
Braga
Query!
Country [291]
0
0
Portugal
Query!
State/province [291]
0
0
Coimbra
Query!
Country [292]
0
0
Portugal
Query!
State/province [292]
0
0
Faro
Query!
Country [293]
0
0
Portugal
Query!
State/province [293]
0
0
Leiria
Query!
Country [294]
0
0
Portugal
Query!
State/province [294]
0
0
Lisboa
Query!
Country [295]
0
0
Portugal
Query!
State/province [295]
0
0
Senhora da Hora
Query!
Country [296]
0
0
Portugal
Query!
State/province [296]
0
0
Setubal
Query!
Country [297]
0
0
Puerto Rico
Query!
State/province [297]
0
0
Bayamon
Query!
Country [298]
0
0
Puerto Rico
Query!
State/province [298]
0
0
Caguas
Query!
Country [299]
0
0
Puerto Rico
Query!
State/province [299]
0
0
Ponce
Query!
Country [300]
0
0
Romania
Query!
State/province [300]
0
0
Arad
Query!
Country [301]
0
0
Romania
Query!
State/province [301]
0
0
Baia Mare
Query!
Country [302]
0
0
Romania
Query!
State/province [302]
0
0
Braila
Query!
Country [303]
0
0
Romania
Query!
State/province [303]
0
0
Bucharest
Query!
Country [304]
0
0
Romania
Query!
State/province [304]
0
0
Buzau
Query!
Country [305]
0
0
Romania
Query!
State/province [305]
0
0
Cluj-Napoca
Query!
Country [306]
0
0
Romania
Query!
State/province [306]
0
0
Craiova
Query!
Country [307]
0
0
Romania
Query!
State/province [307]
0
0
Oradea
Query!
Country [308]
0
0
Romania
Query!
State/province [308]
0
0
Pitesti
Query!
Country [309]
0
0
Romania
Query!
State/province [309]
0
0
Timisoara
Query!
Country [310]
0
0
Russian Federation
Query!
State/province [310]
0
0
Arkhangelsk
Query!
Country [311]
0
0
Russian Federation
Query!
State/province [311]
0
0
Barnaul
Query!
Country [312]
0
0
Russian Federation
Query!
State/province [312]
0
0
Ekaterinburg
Query!
Country [313]
0
0
Russian Federation
Query!
State/province [313]
0
0
Irkutsk
Query!
Country [314]
0
0
Russian Federation
Query!
State/province [314]
0
0
Kazan
Query!
Country [315]
0
0
Russian Federation
Query!
State/province [315]
0
0
Kemerovo
Query!
Country [316]
0
0
Russian Federation
Query!
State/province [316]
0
0
Kirovsk
Query!
Country [317]
0
0
Russian Federation
Query!
State/province [317]
0
0
Moscow
Query!
Country [318]
0
0
Russian Federation
Query!
State/province [318]
0
0
Nizhny Novgorod
Query!
Country [319]
0
0
Russian Federation
Query!
State/province [319]
0
0
Novosibirsk
Query!
Country [320]
0
0
Russian Federation
Query!
State/province [320]
0
0
Omsk
Query!
Country [321]
0
0
Russian Federation
Query!
State/province [321]
0
0
Orenburg
Query!
Country [322]
0
0
Russian Federation
Query!
State/province [322]
0
0
Penza
Query!
Country [323]
0
0
Russian Federation
Query!
State/province [323]
0
0
Petrozavodsk
Query!
Country [324]
0
0
Russian Federation
Query!
State/province [324]
0
0
Saint-Petersburg
Query!
Country [325]
0
0
Russian Federation
Query!
State/province [325]
0
0
Saratov
Query!
Country [326]
0
0
Russian Federation
Query!
State/province [326]
0
0
Tomsk
Query!
Country [327]
0
0
Russian Federation
Query!
State/province [327]
0
0
Tula
Query!
Country [328]
0
0
Russian Federation
Query!
State/province [328]
0
0
Tyumen
Query!
Country [329]
0
0
Russian Federation
Query!
State/province [329]
0
0
Yaroslavl
Query!
Country [330]
0
0
Slovakia
Query!
State/province [330]
0
0
Bardejov
Query!
Country [331]
0
0
Slovakia
Query!
State/province [331]
0
0
Bratislava
Query!
Country [332]
0
0
Slovakia
Query!
State/province [332]
0
0
Kosice
Query!
Country [333]
0
0
Slovakia
Query!
State/province [333]
0
0
Lucenec
Query!
Country [334]
0
0
Slovakia
Query!
State/province [334]
0
0
Namestovo
Query!
Country [335]
0
0
Slovakia
Query!
State/province [335]
0
0
Nitra
Query!
Country [336]
0
0
South Africa
Query!
State/province [336]
0
0
Bloemfontein
Query!
Country [337]
0
0
South Africa
Query!
State/province [337]
0
0
Cape Town
Query!
Country [338]
0
0
South Africa
Query!
State/province [338]
0
0
Gatong
Query!
Country [339]
0
0
South Africa
Query!
State/province [339]
0
0
Johannesburg
Query!
Country [340]
0
0
South Africa
Query!
State/province [340]
0
0
Kuils River
Query!
Country [341]
0
0
South Africa
Query!
State/province [341]
0
0
Paarl
Query!
Country [342]
0
0
South Africa
Query!
State/province [342]
0
0
Parow
Query!
Country [343]
0
0
South Africa
Query!
State/province [343]
0
0
Somerset West
Query!
Country [344]
0
0
South Africa
Query!
State/province [344]
0
0
Worcester
Query!
Country [345]
0
0
Spain
Query!
State/province [345]
0
0
A Coruna
Query!
Country [346]
0
0
Spain
Query!
State/province [346]
0
0
Barcelona
Query!
Country [347]
0
0
Spain
Query!
State/province [347]
0
0
Hospitalet del Llobregat
Query!
Country [348]
0
0
Spain
Query!
State/province [348]
0
0
Lleida
Query!
Country [349]
0
0
Spain
Query!
State/province [349]
0
0
Madrid
Query!
Country [350]
0
0
Spain
Query!
State/province [350]
0
0
Malaga
Query!
Country [351]
0
0
Spain
Query!
State/province [351]
0
0
Sabadell
Query!
Country [352]
0
0
Spain
Query!
State/province [352]
0
0
Salamanca
Query!
Country [353]
0
0
Spain
Query!
State/province [353]
0
0
Sant Joan
Query!
Country [354]
0
0
Spain
Query!
State/province [354]
0
0
Santiago de Compostela
Query!
Country [355]
0
0
Spain
Query!
State/province [355]
0
0
Seville
Query!
Country [356]
0
0
Spain
Query!
State/province [356]
0
0
Tarragona
Query!
Country [357]
0
0
Spain
Query!
State/province [357]
0
0
Valencia
Query!
Country [358]
0
0
Spain
Query!
State/province [358]
0
0
Vigo
Query!
Country [359]
0
0
Sweden
Query!
State/province [359]
0
0
Falun
Query!
Country [360]
0
0
Sweden
Query!
State/province [360]
0
0
Karlshamn
Query!
Country [361]
0
0
Sweden
Query!
State/province [361]
0
0
Koping
Query!
Country [362]
0
0
Sweden
Query!
State/province [362]
0
0
Linkoping
Query!
Country [363]
0
0
Sweden
Query!
State/province [363]
0
0
Malmo
Query!
Country [364]
0
0
Sweden
Query!
State/province [364]
0
0
Orebro
Query!
Country [365]
0
0
Sweden
Query!
State/province [365]
0
0
Umea
Query!
Country [366]
0
0
Sweden
Query!
State/province [366]
0
0
Uppsala
Query!
Country [367]
0
0
Sweden
Query!
State/province [367]
0
0
Vasteras
Query!
Country [368]
0
0
Switzerland
Query!
State/province [368]
0
0
Geneva
Query!
Country [369]
0
0
Switzerland
Query!
State/province [369]
0
0
Lugano
Query!
Country [370]
0
0
Turkey
Query!
State/province [370]
0
0
Afyonkarahisar
Query!
Country [371]
0
0
Turkey
Query!
State/province [371]
0
0
Ankara
Query!
Country [372]
0
0
Turkey
Query!
State/province [372]
0
0
Istanbul
Query!
Country [373]
0
0
Turkey
Query!
State/province [373]
0
0
Izmir
Query!
Country [374]
0
0
Turkey
Query!
State/province [374]
0
0
Kadikoy
Query!
Country [375]
0
0
Turkey
Query!
State/province [375]
0
0
Kayseri
Query!
Country [376]
0
0
Turkey
Query!
State/province [376]
0
0
Mersin
Query!
Country [377]
0
0
Turkey
Query!
State/province [377]
0
0
Samsun
Query!
Country [378]
0
0
Turkey
Query!
State/province [378]
0
0
Sivas
Query!
Country [379]
0
0
United Arab Emirates
Query!
State/province [379]
0
0
Dubai
Query!
Country [380]
0
0
United Arab Emirates
Query!
State/province [380]
0
0
Sharjah
Query!
Country [381]
0
0
United Kingdom
Query!
State/province [381]
0
0
Ayr
Query!
Country [382]
0
0
United Kingdom
Query!
State/province [382]
0
0
Barnet
Query!
Country [383]
0
0
United Kingdom
Query!
State/province [383]
0
0
Basildon
Query!
Country [384]
0
0
United Kingdom
Query!
State/province [384]
0
0
Belfast
Query!
Country [385]
0
0
United Kingdom
Query!
State/province [385]
0
0
Birmingham
Query!
Country [386]
0
0
United Kingdom
Query!
State/province [386]
0
0
Blackpool
Query!
Country [387]
0
0
United Kingdom
Query!
State/province [387]
0
0
Bradford
Query!
Country [388]
0
0
United Kingdom
Query!
State/province [388]
0
0
Bristol
Query!
Country [389]
0
0
United Kingdom
Query!
State/province [389]
0
0
Burton Upon Trent
Query!
Country [390]
0
0
United Kingdom
Query!
State/province [390]
0
0
Chelmsford
Query!
Country [391]
0
0
United Kingdom
Query!
State/province [391]
0
0
Chertsey
Query!
Country [392]
0
0
United Kingdom
Query!
State/province [392]
0
0
Clydebank
Query!
Country [393]
0
0
United Kingdom
Query!
State/province [393]
0
0
Coventry
Query!
Country [394]
0
0
United Kingdom
Query!
State/province [394]
0
0
Craigavon
Query!
Country [395]
0
0
United Kingdom
Query!
State/province [395]
0
0
Dartford
Query!
Country [396]
0
0
United Kingdom
Query!
State/province [396]
0
0
Dudley
Query!
Country [397]
0
0
United Kingdom
Query!
State/province [397]
0
0
Glasgow
Query!
Country [398]
0
0
United Kingdom
Query!
State/province [398]
0
0
Harrow
Query!
Country [399]
0
0
United Kingdom
Query!
State/province [399]
0
0
High Wycombe
Query!
Country [400]
0
0
United Kingdom
Query!
State/province [400]
0
0
Hull
Query!
Country [401]
0
0
United Kingdom
Query!
State/province [401]
0
0
Inverness
Query!
Country [402]
0
0
United Kingdom
Query!
State/province [402]
0
0
Kirkcaldy
Query!
Country [403]
0
0
United Kingdom
Query!
State/province [403]
0
0
Lanark
Query!
Country [404]
0
0
United Kingdom
Query!
State/province [404]
0
0
Leicester
Query!
Country [405]
0
0
United Kingdom
Query!
State/province [405]
0
0
Lincoln
Query!
Country [406]
0
0
United Kingdom
Query!
State/province [406]
0
0
Liverpool
Query!
Country [407]
0
0
United Kingdom
Query!
State/province [407]
0
0
Londonderry
Query!
Country [408]
0
0
United Kingdom
Query!
State/province [408]
0
0
London
Query!
Country [409]
0
0
United Kingdom
Query!
State/province [409]
0
0
Luton
Query!
Country [410]
0
0
United Kingdom
Query!
State/province [410]
0
0
Manchester
Query!
Country [411]
0
0
United Kingdom
Query!
State/province [411]
0
0
Newcastle
Query!
Country [412]
0
0
United Kingdom
Query!
State/province [412]
0
0
Newport
Query!
Country [413]
0
0
United Kingdom
Query!
State/province [413]
0
0
Northampton
Query!
Country [414]
0
0
United Kingdom
Query!
State/province [414]
0
0
Nuneaton
Query!
Country [415]
0
0
United Kingdom
Query!
State/province [415]
0
0
Paisley
Query!
Country [416]
0
0
United Kingdom
Query!
State/province [416]
0
0
Redhill
Query!
Country [417]
0
0
United Kingdom
Query!
State/province [417]
0
0
Romford
Query!
Country [418]
0
0
United Kingdom
Query!
State/province [418]
0
0
Rotherham
Query!
Country [419]
0
0
United Kingdom
Query!
State/province [419]
0
0
Salford
Query!
Country [420]
0
0
United Kingdom
Query!
State/province [420]
0
0
Sheffield
Query!
Country [421]
0
0
United Kingdom
Query!
State/province [421]
0
0
Stevenage
Query!
Country [422]
0
0
United Kingdom
Query!
State/province [422]
0
0
Stockport
Query!
Country [423]
0
0
United Kingdom
Query!
State/province [423]
0
0
Stockton on Tees
Query!
Country [424]
0
0
United Kingdom
Query!
State/province [424]
0
0
Swindon
Query!
Country [425]
0
0
United Kingdom
Query!
State/province [425]
0
0
Taunton
Query!
Country [426]
0
0
United Kingdom
Query!
State/province [426]
0
0
Telford
Query!
Country [427]
0
0
United Kingdom
Query!
State/province [427]
0
0
Truro
Query!
Country [428]
0
0
United Kingdom
Query!
State/province [428]
0
0
West Bromwich
Query!
Country [429]
0
0
United Kingdom
Query!
State/province [429]
0
0
Westcliff on Sea
Query!
Country [430]
0
0
United Kingdom
Query!
State/province [430]
0
0
Wigan
Query!
Country [431]
0
0
United Kingdom
Query!
State/province [431]
0
0
Worcester
Query!
Country [432]
0
0
United Kingdom
Query!
State/province [432]
0
0
Worthing
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
DalCor Pharmaceuticals
Query!
Address
Query!
Country
Query!
Other collaborator category [1]
0
0
Other
Query!
Name [1]
0
0
The Montreal Health Innovations Coordinating Center (MHICC)
Query!
Address [1]
0
0
Query!
Country [1]
0
0
Query!
Other collaborator category [2]
0
0
Commercial sector/industry
Query!
Name [2]
0
0
Medpace, Inc.
Query!
Address [2]
0
0
Query!
Country [2]
0
0
Query!
Other collaborator category [3]
0
0
Commercial sector/industry
Query!
Name [3]
0
0
Roche Molecular Systems, Inc
Query!
Address [3]
0
0
Query!
Country [3]
0
0
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
A placebo-controlled, randomized, double-blind, parallel group, phase III multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile. Subjects will provide informed consent before any study-specific procedures are performed. Subject enrollment may begin in the hospital and will continue following release from the hospital. Screening procedures may be performed at the time of the index ACS event or anytime thereafter, with the condition that randomization must occur within the mandated window (4-12 weeks after the index event). Subjects will be assessed based on their medical history. Those who are likely to qualify will undergo Genotype Assay testing to evaluate genetic determination for the presence of AA genotype.
Query!
Trial website
https://clinicaltrials.gov/study/NCT02525939
Query!
Trial related presentations / publications
Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Mooser V, Waters DD, Gregoire JC, L'Allier PL, Wouter Jukema J, White HD, Heinonen T, Black DM, Laghrissi-Thode F, Levesque S, Guertin MC, Dube MP; dal-GenE Investigators. Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial. Eur Heart J. 2022 Oct 14;43(39):3947-3956. doi: 10.1093/eurheartj/ehac374. Erratum In: Eur Heart J. 2022 Nov 21;43(44):4656. doi: 10.1093/eurheartj/ehac534. Black DM, Miller M, Heinonen TM, Zhang G. Advancing Beyond Failed High-density Lipoprotein Clinical Trials to Pharmacogenetic Studies of ADCY9 and Cholesterol Ester Transfer Protein Inhibition. J Cardiovasc Pharmacol. 2021 Oct 1;78(4):496-500. doi: 10.1097/FJC.0000000000001093. Tardif JC, Dube MP, Pfeffer MA, Waters DD, Koenig W, Maggioni AP, McMurray JJV, Mooser V, White HD, Heinonen T, Black DM, Guertin MC; dal-GenE Investigators. Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib. Am Heart J. 2020 Apr;222:157-165. doi: 10.1016/j.ahj.2020.01.007. Epub 2020 Jan 17.
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
Donald M Black, MD
Query!
Address
0
0
DalCor Pharmaceuticals
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
Query!
No/undecided IPD sharing reason/comment
Query!
What supporting documents are/will be available?
No Supporting Document Provided
Type
Other Details
Attachment
Study protocol
https://cdn.clinicaltrials.gov/large-docs/39/NCT02525939/Prot_000.pdf
Statistical analysis plan
https://cdn.clinicaltrials.gov/large-docs/39/NCT02525939/SAP_001.pdf
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT02525939