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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01994720
Registration number
NCT01994720
Ethics application status
Date submitted
18/11/2013
Date registered
26/11/2013
Date last updated
12/06/2017
Titles & IDs
Public title
[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]
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Scientific title
A Randomised, Double-Blind, Multinational Study to Prevent Major Vascular Events With Ticagrelor Compared to Aspirin (ASA) in Patients With Acute Ischaemic Stroke or TIA.
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Secondary ID [1]
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2012-003895-38
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Secondary ID [2]
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D5134C00001
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Universal Trial Number (UTN)
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Trial acronym
SOCRATES
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Acute Ischaemic Stroke
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0
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Transient Ischaemic Attack
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Condition category
Condition code
Stroke
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0
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Haemorrhagic
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Stroke
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0
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Ischaemic
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Cardiovascular
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0
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Diseases of the vasculature and circulation including the lymphatic system
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Neurological
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0
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Other neurological disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - ticagrelor
Treatment: Drugs - Acetylsalicylic acid (ASA)
Experimental: ticagrelor -
Active comparator: Acetylsalicylic acid (ASA) -
Treatment: Drugs: ticagrelor
ticagrelor, 180 mg (two tablets of 90 mg) loading dose on Day 1 followed by 90 mg twice daily.
Treatment: Drugs: Acetylsalicylic acid (ASA)
ASA, 300 mg (three tablets of 100 mg) on Day 1, followed by 100 mg once daily.
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Number of Participants With Composite of Stroke/MI/Death
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Assessment method [1]
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Participants with stroke, MI or death. If no event, censoring occures at the minimum of (last date of event assessment, end of treatment date, day 97).
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Timepoint [1]
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From randomization up to 97 days
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Secondary outcome [1]
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Number of Participants With Ischaemic Stroke
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Assessment method [1]
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Participants with ischaemic stroke. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97).
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Timepoint [1]
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From randomization up to 97 days
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Secondary outcome [2]
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Net Clinical Outcome
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Assessment method [2]
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Participants with stroke, MI, death or life-threatening bleeding. If no event, censoring occures at the minimum of (last date of event assessment, end of treatment date, day 97).
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Timepoint [2]
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From randomization up to 97 days
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Secondary outcome [3]
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Number of Participants With Composite of Ischaemic Stroke, MI and CV Death
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Assessment method [3]
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Participants with ischaemic stroke, MI or CV death. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97).
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Timepoint [3]
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From randomization up to 97 days
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Secondary outcome [4]
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Number of Participants With All-Cause Death
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Assessment method [4]
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Participants with all-cause death. If no event, censoring at the minimum of (last date of event assessment, end of treatment date, day 97).
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Timepoint [4]
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From randomization up to 97 days
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Secondary outcome [5]
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Number of Participants With CV Death
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Assessment method [5]
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Participants with CV death. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97).
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Timepoint [5]
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From randomization up to 97 days
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Secondary outcome [6]
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Number of Participants With MI
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Assessment method [6]
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Participants with MI. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97)
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Timepoint [6]
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From randomization up to 97 days
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Secondary outcome [7]
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Number of Participants by Severity of Stroke and Overall Disability
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Assessment method [7]
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Analysis of severity of stroke and overall disability of patients, using the modified Rankin Score, mRS.
Modified Rankin Score:
0 - No symptoms.
1. - No significant disability. Able to carry out all usual activities, despite some symptoms.
2. - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.
3. - Moderate disability. Requires some help, but able to walk unassisted.
4. - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.
5. - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.
6. - Dead.
Disability defined as mRS \> 1.
Odds ratio and p-value are calculated for ticagrelor versus ASA from a logistic regression model with treatment group, history of stroke and NIHSS (National Institutes of Health Stroke Scale) at baseline as explanatory variables.
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Timepoint [7]
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From randomization up to 97 days
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Secondary outcome [8]
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Number of Participants With Stroke
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Assessment method [8]
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Participants with stroke. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97)
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Timepoint [8]
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From randomization up to 97 days
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Secondary outcome [9]
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Number of Participants With Fatal Stroke
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Assessment method [9]
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Participants with fatal stroke. If no event, censoring at the minimum of (last date of event assessment, date of death from non-CV causes, end of treatment date, day 97).
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Timepoint [9]
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From randomization up to 97 days
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Secondary outcome [10]
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Number of Participants With Disabling Stroke
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Assessment method [10]
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Participants with disabling stroke. If no event, censoring at the minimum of (last date of event assessment, date of death, end of treatment date, day 97).
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Timepoint [10]
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From randomization up to 97 days
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Secondary outcome [11]
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Change in NIHSS
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Assessment method [11]
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Change from baseline to end of treatment visit in NIHSS (National Institutes of Health Stroke Scale):
0 No stroke symptoms 1-4 Minor stroke 5-15 Moderate stroke 16-20 Moderate to severe stroke 21-42 Severe stroke.
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Timepoint [11]
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From randomization up to 97 days
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Secondary outcome [12]
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EQ-5D at Visit 1 (Enrolment)
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Assessment method [12]
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EQ-5D (EuroQol five dimensions questionnaire) index score using the UK tariff.
EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.
The higher the index score the better the health state. In this study index scores ran from -0.59 to 1.
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Timepoint [12]
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Visit 1 (Enrolment)
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Secondary outcome [13]
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EQ-5D at Visit 2 (Day 7+-2d)
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Assessment method [13]
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EQ-5D (EuroQol five dimensions questionnaire) index score using the UK tariff.
EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.
The higher the index score the better the health state. In this study index scores ran from -0.59 to 1.
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Timepoint [13]
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Visit 2 (Day 7+-2d)
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Secondary outcome [14]
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EQ-5D (EuroQol Five Dimensions Questionnaire) at End of Treatment Visit
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Assessment method [14]
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EQ-5D index score using the UK tariff.
EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.
The higher the index score the better the health state. In this study index scores ran from -0.59 to 1.
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Timepoint [14]
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End of treatment visit (Day 90+-7d)
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Secondary outcome [15]
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EQ-5D (EuroQol Five Dimensions Questionnaire) at Premature Treatment Discontinuation Visit
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Assessment method [15]
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EQ-5D index score using the UK tariff.
EQ-5D is a self assessment of 5 dimensions: mobility, self-care, usual activities, pain and discomfort, and anxiety and depression. For each dimension responders are asked to state their status on a three level ordinal scale; whether they experience no problems (Level 1), some problems (Level 2) or severe problems (Level 3). Health states defined by the 5 dimensions can be converted into a weighted health state index (health state utility) by applying scores from the EQ-5D value sets elicited from general population samples.
The higher the index score the better the health state. In this study index scores ran from -0.59 to 1.
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Timepoint [15]
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Premature treatment discontinuation visit(<15 days after last dose)
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Secondary outcome [16]
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Number of Participants With PLATO Major Bleeding Event
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Assessment method [16]
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Participants with PLATO Major bleeding. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97).
PLATO Major bleeding is defined as a bleed that is any one of:
* Fatal
* Intracranial (excluding asymptomatic haemorrhagic transformations of ischemic brain infarctions and excluding micro-hemorrhages \<10 mm evident only on gradient-echo MRI)
* Intrapericardial bleed with cardiac tamponade
* Hypovolaemic shock or severe hypotension due to bleeding and requiring pressors or surgery
* Significantly disabling (eg. intraocular with permanent vision loss)
* Clinically overt or apparent bleeding associated with a decrease in Hb of more than 30 g/L (1.9 mmol/L; 0.465 mmol/L)
* Transfusion of 2 or more units (whole blood or packed red blood cells \[PRBCs\]) for bleeding.
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Timepoint [16]
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From randomization up to 97 days
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Secondary outcome [17]
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Number of Participants With Premature Discontinuation of Study Drug Due to Any Bleeding Adverse Event
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Assessment method [17]
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Participants discontinuation of study drug due to any bleeding adverse event. If no event, censoring occures at the minimum of (last date of event assessment, date of death, end of treatment date, day 97).
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Timepoint [17]
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Time from first dose and up to and including 7 days following the date of last dose of the study
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Eligibility
Key inclusion criteria
* Men or women equal or elder 40 years of age
* Either acute ischaemic stroke or high-risk TIA as defined here and randomisation occurring within 24 hours after onset of symptoms
Key
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Minimum age
40
Years
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Maximum age
130
Years
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Planned use of antithrombotic therapy in addition to study medication including antiplatelets (eg, open label ASA, GPIIb/IIIa inhibitors, clopidogrel, ticlopidine, prasugrel, dipyridamole, ozagrel, cilostazol) and anticoagulants (eg, warfarin, oral thrombin and factor Xa inhibitors, bivalirudin, hirudin, argatroban, unfractionated and low molecular weight heparins). - Any history of atrial fibrillation, ventricular aneurysm or suspicion of cardioembolic pathology for TIA or stroke. - Planned carotid, cerebrovascular, or coronary revascularisation that requires halting study medication within 7 days of randomisation. - Receipt of any intravenous or intra-arterial thrombolysis or mechanical thrombectomy within 24 hours prior to randomisation - History of previous symptomatic non-traumatic intracerebral bleed at any time (asymptomatic microbleeds do not qualify), gastrointestinal (GI) bleed within the past 6 months, or major surgery within 30 days.
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Study design
Purpose of the study
Prevention
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
7/01/2014
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
2/03/2016
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Sample size
Target
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Accrual to date
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Final
13307
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Recruitment in Australia
Recruitment state(s)
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Recruitment hospital [1]
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Research Site - Adelaide
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Recruitment hospital [2]
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Research Site - Bedford Park
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Recruitment hospital [3]
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Research Site - Camperdown
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Recruitment hospital [4]
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Research Site - Clayton
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Recruitment hospital [5]
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Research Site - Darlinghurst
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Recruitment hospital [6]
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Research Site - Footscray
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Recruitment hospital [7]
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Research Site - Herston
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Recruitment hospital [8]
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Research Site - New Lambton Heights
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Recruitment hospital [9]
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Research Site - Parkville
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Recruitment hospital [10]
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Research Site - Southport
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Recruitment hospital [11]
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Research Site - Sydney
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Recruitment hospital [12]
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Research Site - Woodville
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Recruitment postcode(s) [1]
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- Adelaide
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Recruitment postcode(s) [2]
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- Bedford Park
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- Camperdown
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- Clayton
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- Darlinghurst
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- Footscray
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Recruitment postcode(s) [7]
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- Herston
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Recruitment postcode(s) [8]
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- New Lambton Heights
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Recruitment postcode(s) [9]
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- Parkville
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Recruitment postcode(s) [10]
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- Southport
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Recruitment postcode(s) [11]
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- Sydney
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Recruitment postcode(s) [12]
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- Woodville
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Recruitment outside Australia
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Alabama
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Pleven
Query!
Country [68]
0
0
Bulgaria
Query!
State/province [68]
0
0
Plovdiv
Query!
Country [69]
0
0
Bulgaria
Query!
State/province [69]
0
0
Ruse
Query!
Country [70]
0
0
Bulgaria
Query!
State/province [70]
0
0
Sandanski
Query!
Country [71]
0
0
Bulgaria
Query!
State/province [71]
0
0
Sliven
Query!
Country [72]
0
0
Bulgaria
Query!
State/province [72]
0
0
Sofia
Query!
Country [73]
0
0
Bulgaria
Query!
State/province [73]
0
0
Teteven
Query!
Country [74]
0
0
Bulgaria
Query!
State/province [74]
0
0
Yambol
Query!
Country [75]
0
0
Canada
Query!
State/province [75]
0
0
Alberta
Query!
Country [76]
0
0
Canada
Query!
State/province [76]
0
0
British Columbia
Query!
Country [77]
0
0
Canada
Query!
State/province [77]
0
0
Newfoundland and Labrador
Query!
Country [78]
0
0
Canada
Query!
State/province [78]
0
0
Ontario
Query!
Country [79]
0
0
Canada
Query!
State/province [79]
0
0
Quebec
Query!
Country [80]
0
0
Chile
Query!
State/province [80]
0
0
Concepcion
Query!
Country [81]
0
0
Chile
Query!
State/province [81]
0
0
Los Angeles
Query!
Country [82]
0
0
Chile
Query!
State/province [82]
0
0
Santiago
Query!
Country [83]
0
0
Chile
Query!
State/province [83]
0
0
Talcahuano
Query!
Country [84]
0
0
Chile
Query!
State/province [84]
0
0
Temuco
Query!
Country [85]
0
0
Chile
Query!
State/province [85]
0
0
Valdivia
Query!
Country [86]
0
0
Chile
Query!
State/province [86]
0
0
Viña del Mar
Query!
Country [87]
0
0
China
Query!
State/province [87]
0
0
Baotou
Query!
Country [88]
0
0
China
Query!
State/province [88]
0
0
Beijing
Query!
Country [89]
0
0
China
Query!
State/province [89]
0
0
Changchun
Query!
Country [90]
0
0
China
Query!
State/province [90]
0
0
Changsha
Query!
Country [91]
0
0
China
Query!
State/province [91]
0
0
Chongqin
Query!
Country [92]
0
0
China
Query!
State/province [92]
0
0
Guang Zhou
Query!
Country [93]
0
0
China
Query!
State/province [93]
0
0
Guangzhou
Query!
Country [94]
0
0
China
Query!
State/province [94]
0
0
Guilin
Query!
Country [95]
0
0
China
Query!
State/province [95]
0
0
Haikou
Query!
Country [96]
0
0
China
Query!
State/province [96]
0
0
Hangzhou
Query!
Country [97]
0
0
China
Query!
State/province [97]
0
0
Harbin
Query!
Country [98]
0
0
China
Query!
State/province [98]
0
0
Huai'an
Query!
Country [99]
0
0
China
Query!
State/province [99]
0
0
Jinan
Query!
Country [100]
0
0
China
Query!
State/province [100]
0
0
Lanzhou
Query!
Country [101]
0
0
China
Query!
State/province [101]
0
0
Linhai
Query!
Country [102]
0
0
China
Query!
State/province [102]
0
0
Nanjing
Query!
Country [103]
0
0
China
Query!
State/province [103]
0
0
Ningbo
Query!
Country [104]
0
0
China
Query!
State/province [104]
0
0
Shanghai
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Shenyang
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Taiyuan
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Tianjin
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Wenzhou
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Wu Han
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Xi'an
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Xiamen
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Yangzhou
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Zhanjiang
Query!
Country [114]
0
0
Czechia
Query!
State/province [114]
0
0
Brno
Query!
Country [115]
0
0
Czechia
Query!
State/province [115]
0
0
Chomutov
Query!
Country [116]
0
0
Czechia
Query!
State/province [116]
0
0
Hradec Kralove
Query!
Country [117]
0
0
Czechia
Query!
State/province [117]
0
0
Jihlava
Query!
Country [118]
0
0
Czechia
Query!
State/province [118]
0
0
Liberec
Query!
Country [119]
0
0
Czechia
Query!
State/province [119]
0
0
Olomouc
Query!
Country [120]
0
0
Czechia
Query!
State/province [120]
0
0
Ostrava
Query!
Country [121]
0
0
Czechia
Query!
State/province [121]
0
0
Pardubice
Query!
Country [122]
0
0
Czechia
Query!
State/province [122]
0
0
Praha 2
Query!
Country [123]
0
0
Czechia
Query!
State/province [123]
0
0
Trutnov
Query!
Country [124]
0
0
France
Query!
State/province [124]
0
0
Antony
Query!
Country [125]
0
0
France
Query!
State/province [125]
0
0
Bayonne
Query!
Country [126]
0
0
France
Query!
State/province [126]
0
0
Bordeaux Cedex
Query!
Country [127]
0
0
France
Query!
State/province [127]
0
0
Bourg en Bresse
Query!
Country [128]
0
0
France
Query!
State/province [128]
0
0
Brest Cedex 2
Query!
Country [129]
0
0
France
Query!
State/province [129]
0
0
Bron
Query!
Country [130]
0
0
France
Query!
State/province [130]
0
0
Caen
Query!
Country [131]
0
0
France
Query!
State/province [131]
0
0
Corbeil Essonnes Cedex
Query!
Country [132]
0
0
France
Query!
State/province [132]
0
0
Creteil
Query!
Country [133]
0
0
France
Query!
State/province [133]
0
0
Dijon
Query!
Country [134]
0
0
France
Query!
State/province [134]
0
0
La Roche sur Yon
Query!
Country [135]
0
0
France
Query!
State/province [135]
0
0
Le Chesnay Cedex
Query!
Country [136]
0
0
France
Query!
State/province [136]
0
0
Le Coudray Cedex
Query!
Country [137]
0
0
France
Query!
State/province [137]
0
0
Lille
Query!
Country [138]
0
0
France
Query!
State/province [138]
0
0
NICE Cedex 01
Query!
Country [139]
0
0
France
Query!
State/province [139]
0
0
PARIS Cedex 12
Query!
Country [140]
0
0
France
Query!
State/province [140]
0
0
Paris Cedex 13
Query!
Country [141]
0
0
France
Query!
State/province [141]
0
0
Paris Cedex 18
Query!
Country [142]
0
0
France
Query!
State/province [142]
0
0
Paris
Query!
Country [143]
0
0
France
Query!
State/province [143]
0
0
Pringy Cedex
Query!
Country [144]
0
0
France
Query!
State/province [144]
0
0
Rennes
Query!
Country [145]
0
0
France
Query!
State/province [145]
0
0
Rouen Cedex
Query!
Country [146]
0
0
France
Query!
State/province [146]
0
0
Saint Herblain
Query!
Country [147]
0
0
France
Query!
State/province [147]
0
0
Saint-priest En Jarez
Query!
Country [148]
0
0
France
Query!
State/province [148]
0
0
Strasbourg Cedex
Query!
Country [149]
0
0
France
Query!
State/province [149]
0
0
Toulouse
Query!
Country [150]
0
0
France
Query!
State/province [150]
0
0
Tours
Query!
Country [151]
0
0
Germany
Query!
State/province [151]
0
0
Altenburg
Query!
Country [152]
0
0
Germany
Query!
State/province [152]
0
0
Bad Neustadt
Query!
Country [153]
0
0
Germany
Query!
State/province [153]
0
0
Berlin
Query!
Country [154]
0
0
Germany
Query!
State/province [154]
0
0
Erlangen
Query!
Country [155]
0
0
Germany
Query!
State/province [155]
0
0
Essen
Query!
Country [156]
0
0
Germany
Query!
State/province [156]
0
0
Frankfurt
Query!
Country [157]
0
0
Germany
Query!
State/province [157]
0
0
Hamburg
Query!
Country [158]
0
0
Germany
Query!
State/province [158]
0
0
Karlsruhe
Query!
Country [159]
0
0
Germany
Query!
State/province [159]
0
0
Kassel
Query!
Country [160]
0
0
Germany
Query!
State/province [160]
0
0
Minden
Query!
Country [161]
0
0
Germany
Query!
State/province [161]
0
0
Münster
Query!
Country [162]
0
0
Germany
Query!
State/province [162]
0
0
Osnabrück
Query!
Country [163]
0
0
Germany
Query!
State/province [163]
0
0
Wiesbaden
Query!
Country [164]
0
0
Hong Kong
Query!
State/province [164]
0
0
Hong Kong
Query!
Country [165]
0
0
Hong Kong
Query!
State/province [165]
0
0
Hongkong
Query!
Country [166]
0
0
Hong Kong
Query!
State/province [166]
0
0
Kowloon
Query!
Country [167]
0
0
Hong Kong
Query!
State/province [167]
0
0
Shatin
Query!
Country [168]
0
0
Hungary
Query!
State/province [168]
0
0
Balassagyarmat
Query!
Country [169]
0
0
Hungary
Query!
State/province [169]
0
0
Budapest
Query!
Country [170]
0
0
Hungary
Query!
State/province [170]
0
0
Debrecen
Query!
Country [171]
0
0
Hungary
Query!
State/province [171]
0
0
Gyor
Query!
Country [172]
0
0
Hungary
Query!
State/province [172]
0
0
Kistarcsa
Query!
Country [173]
0
0
Hungary
Query!
State/province [173]
0
0
Miskolc
Query!
Country [174]
0
0
Hungary
Query!
State/province [174]
0
0
Nagykanizsa
Query!
Country [175]
0
0
Hungary
Query!
State/province [175]
0
0
Nyíregyháza
Query!
Country [176]
0
0
Hungary
Query!
State/province [176]
0
0
Pécs
Query!
Country [177]
0
0
Hungary
Query!
State/province [177]
0
0
Sopron-Balf
Query!
Country [178]
0
0
Hungary
Query!
State/province [178]
0
0
Szekszárd
Query!
Country [179]
0
0
Hungary
Query!
State/province [179]
0
0
Székesfehérvár
Query!
Country [180]
0
0
Israel
Query!
State/province [180]
0
0
Haifa
Query!
Country [181]
0
0
Israel
Query!
State/province [181]
0
0
Holon
Query!
Country [182]
0
0
Israel
Query!
State/province [182]
0
0
Jerusalem
Query!
Country [183]
0
0
Israel
Query!
State/province [183]
0
0
Petach Tikva
Query!
Country [184]
0
0
Israel
Query!
State/province [184]
0
0
Ramat Gan
Query!
Country [185]
0
0
Israel
Query!
State/province [185]
0
0
Tel Aviv
Query!
Country [186]
0
0
Italy
Query!
State/province [186]
0
0
Carrara
Query!
Country [187]
0
0
Italy
Query!
State/province [187]
0
0
Citta' di Castello
Query!
Country [188]
0
0
Italy
Query!
State/province [188]
0
0
Foligno
Query!
Country [189]
0
0
Italy
Query!
State/province [189]
0
0
Genova
Query!
Country [190]
0
0
Italy
Query!
State/province [190]
0
0
Gubbio
Query!
Country [191]
0
0
Italy
Query!
State/province [191]
0
0
Lecco
Query!
Country [192]
0
0
Italy
Query!
State/province [192]
0
0
Milano
Query!
Country [193]
0
0
Italy
Query!
State/province [193]
0
0
Modena
Query!
Country [194]
0
0
Italy
Query!
State/province [194]
0
0
Pavia
Query!
Country [195]
0
0
Italy
Query!
State/province [195]
0
0
Perugia
Query!
Country [196]
0
0
Italy
Query!
State/province [196]
0
0
Piacenza
Query!
Country [197]
0
0
Italy
Query!
State/province [197]
0
0
Pisa
Query!
Country [198]
0
0
Italy
Query!
State/province [198]
0
0
Reggio Emilia
Query!
Country [199]
0
0
Italy
Query!
State/province [199]
0
0
Roma
Query!
Country [200]
0
0
Italy
Query!
State/province [200]
0
0
Rozzano
Query!
Country [201]
0
0
Italy
Query!
State/province [201]
0
0
Siena
Query!
Country [202]
0
0
Italy
Query!
State/province [202]
0
0
Varese
Query!
Country [203]
0
0
Italy
Query!
State/province [203]
0
0
Verona
Query!
Country [204]
0
0
Italy
Query!
State/province [204]
0
0
Vibo Valentia
Query!
Country [205]
0
0
Japan
Query!
State/province [205]
0
0
Aki-gun
Query!
Country [206]
0
0
Japan
Query!
State/province [206]
0
0
Asahikawa-shi
Query!
Country [207]
0
0
Japan
Query!
State/province [207]
0
0
Chiba-shi
Query!
Country [208]
0
0
Japan
Query!
State/province [208]
0
0
Chikushi-gun
Query!
Country [209]
0
0
Japan
Query!
State/province [209]
0
0
Chikushino-shi
Query!
Country [210]
0
0
Japan
Query!
State/province [210]
0
0
Chitose-shi
Query!
Country [211]
0
0
Japan
Query!
State/province [211]
0
0
Daito-shi
Query!
Country [212]
0
0
Japan
Query!
State/province [212]
0
0
Date-gun
Query!
Country [213]
0
0
Japan
Query!
State/province [213]
0
0
Eniwa-shi
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Fujinomiya-shi
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Fukui-shi
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Fukuoka-shi
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Fukushima-shi
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Fukuyama-shi
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Gifu-shi
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Hachioji-shi
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Hakodate-shi
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Hamada-shi
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Hanamaki-shi
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Hatsukaichi-shi
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Hidaka-shi
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Higashiibaraki-gun
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Higashiosaka-shi
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Hitachi-shi
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Ina-shi
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Itami-shi
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Izumisano-shi
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Izumo-shi
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Kaga-shi
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Kagoshima-shi
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Kakegawa-shi
Query!
Country [236]
0
0
Japan
Query!
State/province [236]
0
0
Kamakura-shi
Query!
Country [237]
0
0
Japan
Query!
State/province [237]
0
0
Kashiwazaki-shi
Query!
Country [238]
0
0
Japan
Query!
State/province [238]
0
0
Kasuga-shi
Query!
Country [239]
0
0
Japan
Query!
State/province [239]
0
0
Kawasaki-shi
Query!
Country [240]
0
0
Japan
Query!
State/province [240]
0
0
Kobe-shi
Query!
Country [241]
0
0
Japan
Query!
State/province [241]
0
0
Kochi-shi
Query!
Country [242]
0
0
Japan
Query!
State/province [242]
0
0
Koga-shi
Query!
Country [243]
0
0
Japan
Query!
State/province [243]
0
0
Komatsu-shi
Query!
Country [244]
0
0
Japan
Query!
State/province [244]
0
0
Komoro-shi
Query!
Country [245]
0
0
Japan
Query!
State/province [245]
0
0
Koshigaya-shi
Query!
Country [246]
0
0
Japan
Query!
State/province [246]
0
0
Kumamoto-shi
Query!
Country [247]
0
0
Japan
Query!
State/province [247]
0
0
Kure-shi
Query!
Country [248]
0
0
Japan
Query!
State/province [248]
0
0
Kurume-shi
Query!
Country [249]
0
0
Japan
Query!
State/province [249]
0
0
Kyoto-shi
Query!
Country [250]
0
0
Japan
Query!
State/province [250]
0
0
Maizuru-shi
Query!
Country [251]
0
0
Japan
Query!
State/province [251]
0
0
Marugame-shi
Query!
Country [252]
0
0
Japan
Query!
State/province [252]
0
0
Matsudo-shi
Query!
Country [253]
0
0
Japan
Query!
State/province [253]
0
0
Matsuyama-shi
Query!
Country [254]
0
0
Japan
Query!
State/province [254]
0
0
Nagano-shi
Query!
Country [255]
0
0
Japan
Query!
State/province [255]
0
0
Nagasaki-shi
Query!
Country [256]
0
0
Japan
Query!
State/province [256]
0
0
Nagoya-shi
Query!
Country [257]
0
0
Japan
Query!
State/province [257]
0
0
Nakano-ku
Query!
Country [258]
0
0
Japan
Query!
State/province [258]
0
0
Nakano-shi
Query!
Country [259]
0
0
Japan
Query!
State/province [259]
0
0
Narita-shi
Query!
Country [260]
0
0
Japan
Query!
State/province [260]
0
0
Nihonmatsu-shi
Query!
Country [261]
0
0
Japan
Query!
State/province [261]
0
0
Okayama-shi
Query!
Country [262]
0
0
Japan
Query!
State/province [262]
0
0
Okinawa-shi
Query!
Country [263]
0
0
Japan
Query!
State/province [263]
0
0
Onga-gun
Query!
Country [264]
0
0
Japan
Query!
State/province [264]
0
0
Ookawa-shi
Query!
Country [265]
0
0
Japan
Query!
State/province [265]
0
0
Osaka-shi
Query!
Country [266]
0
0
Japan
Query!
State/province [266]
0
0
Saga-shi
Query!
Country [267]
0
0
Japan
Query!
State/province [267]
0
0
Sagamihara-shi
Query!
Country [268]
0
0
Japan
Query!
State/province [268]
0
0
Saijo-shi
Query!
Country [269]
0
0
Japan
Query!
State/province [269]
0
0
Sakai-shi
Query!
Country [270]
0
0
Japan
Query!
State/province [270]
0
0
Sanuki-shi
Query!
Country [271]
0
0
Japan
Query!
State/province [271]
0
0
Sapporo-shi
Query!
Country [272]
0
0
Japan
Query!
State/province [272]
0
0
Sayama-shi
Query!
Country [273]
0
0
Japan
Query!
State/province [273]
0
0
Sendai-shi
Query!
Country [274]
0
0
Japan
Query!
State/province [274]
0
0
Shiroishi-shi
Query!
Country [275]
0
0
Japan
Query!
State/province [275]
0
0
Shizuoka-shi
Query!
Country [276]
0
0
Japan
Query!
State/province [276]
0
0
Suita-shi
Query!
Country [277]
0
0
Japan
Query!
State/province [277]
0
0
Suwa-shi
Query!
Country [278]
0
0
Japan
Query!
State/province [278]
0
0
Tachikawa-shi
Query!
Country [279]
0
0
Japan
Query!
State/province [279]
0
0
Takasaki-shi
Query!
Country [280]
0
0
Japan
Query!
State/province [280]
0
0
Takayama-shi
Query!
Country [281]
0
0
Japan
Query!
State/province [281]
0
0
Tokushima-shi
Query!
Country [282]
0
0
Japan
Query!
State/province [282]
0
0
Toyama-shi
Query!
Country [283]
0
0
Japan
Query!
State/province [283]
0
0
Toyohashi-shi
Query!
Country [284]
0
0
Japan
Query!
State/province [284]
0
0
Toyota-shi
Query!
Country [285]
0
0
Japan
Query!
State/province [285]
0
0
Tsu-shi
Query!
Country [286]
0
0
Japan
Query!
State/province [286]
0
0
Ube-shi
Query!
Country [287]
0
0
Japan
Query!
State/province [287]
0
0
Ueda-shi
Query!
Country [288]
0
0
Japan
Query!
State/province [288]
0
0
Uji-shi
Query!
Country [289]
0
0
Japan
Query!
State/province [289]
0
0
Ureshino-shi
Query!
Country [290]
0
0
Japan
Query!
State/province [290]
0
0
Utsunomiya-shi
Query!
Country [291]
0
0
Japan
Query!
State/province [291]
0
0
Yokohama-shi
Query!
Country [292]
0
0
Japan
Query!
State/province [292]
0
0
Zentsuji-shi
Query!
Country [293]
0
0
Korea, Republic of
Query!
State/province [293]
0
0
Busan
Query!
Country [294]
0
0
Korea, Republic of
Query!
State/province [294]
0
0
Daegu
Query!
Country [295]
0
0
Korea, Republic of
Query!
State/province [295]
0
0
Gwangju
Query!
Country [296]
0
0
Korea, Republic of
Query!
State/province [296]
0
0
Incheon
Query!
Country [297]
0
0
Korea, Republic of
Query!
State/province [297]
0
0
Seongnam-si
Query!
Country [298]
0
0
Korea, Republic of
Query!
State/province [298]
0
0
Seoul
Query!
Country [299]
0
0
Korea, Republic of
Query!
State/province [299]
0
0
Wonju-si
Query!
Country [300]
0
0
Mexico
Query!
State/province [300]
0
0
Aguascalientes
Query!
Country [301]
0
0
Mexico
Query!
State/province [301]
0
0
Culiacan
Query!
Country [302]
0
0
Mexico
Query!
State/province [302]
0
0
D.F
Query!
Country [303]
0
0
Mexico
Query!
State/province [303]
0
0
Del. Cuauhtemoc
Query!
Country [304]
0
0
Mexico
Query!
State/province [304]
0
0
Distrito Federal
Query!
Country [305]
0
0
Mexico
Query!
State/province [305]
0
0
Monterrey
Query!
Country [306]
0
0
Peru
Query!
State/province [306]
0
0
Bellavista
Query!
Country [307]
0
0
Peru
Query!
State/province [307]
0
0
Callao
Query!
Country [308]
0
0
Peru
Query!
State/province [308]
0
0
Cusco
Query!
Country [309]
0
0
Peru
Query!
State/province [309]
0
0
Lima
Query!
Country [310]
0
0
Philippines
Query!
State/province [310]
0
0
Baguio City
Query!
Country [311]
0
0
Philippines
Query!
State/province [311]
0
0
Cagayan de Oro City
Query!
Country [312]
0
0
Philippines
Query!
State/province [312]
0
0
Cebu
Query!
Country [313]
0
0
Philippines
Query!
State/province [313]
0
0
Iloilo City
Query!
Country [314]
0
0
Philippines
Query!
State/province [314]
0
0
Manila
Query!
Country [315]
0
0
Philippines
Query!
State/province [315]
0
0
Pasay City
Query!
Country [316]
0
0
Philippines
Query!
State/province [316]
0
0
Pasig City
Query!
Country [317]
0
0
Philippines
Query!
State/province [317]
0
0
Quezon City
Query!
Country [318]
0
0
Poland
Query!
State/province [318]
0
0
Bialystok
Query!
Country [319]
0
0
Poland
Query!
State/province [319]
0
0
Chelm
Query!
Country [320]
0
0
Poland
Query!
State/province [320]
0
0
Dzialdowo
Query!
Country [321]
0
0
Poland
Query!
State/province [321]
0
0
Gdansk
Query!
Country [322]
0
0
Poland
Query!
State/province [322]
0
0
Gryfice
Query!
Country [323]
0
0
Poland
Query!
State/province [323]
0
0
Katowice
Query!
Country [324]
0
0
Poland
Query!
State/province [324]
0
0
Kielce
Query!
Country [325]
0
0
Poland
Query!
State/province [325]
0
0
Konskie
Query!
Country [326]
0
0
Poland
Query!
State/province [326]
0
0
Kraków
Query!
Country [327]
0
0
Poland
Query!
State/province [327]
0
0
Lublin
Query!
Country [328]
0
0
Poland
Query!
State/province [328]
0
0
Olsztyn
Query!
Country [329]
0
0
Poland
Query!
State/province [329]
0
0
Ostroleka
Query!
Country [330]
0
0
Poland
Query!
State/province [330]
0
0
Sandomierz
Query!
Country [331]
0
0
Poland
Query!
State/province [331]
0
0
Warszawa
Query!
Country [332]
0
0
Poland
Query!
State/province [332]
0
0
Wloclawek
Query!
Country [333]
0
0
Poland
Query!
State/province [333]
0
0
Lódz
Query!
Country [334]
0
0
Romania
Query!
State/province [334]
0
0
Bucharest
Query!
Country [335]
0
0
Romania
Query!
State/province [335]
0
0
Iasi
Query!
Country [336]
0
0
Romania
Query!
State/province [336]
0
0
Oradea
Query!
Country [337]
0
0
Romania
Query!
State/province [337]
0
0
Sibiu
Query!
Country [338]
0
0
Romania
Query!
State/province [338]
0
0
Timisoara
Query!
Country [339]
0
0
Romania
Query!
State/province [339]
0
0
Tirgu-Mures
Query!
Country [340]
0
0
Russian Federation
Query!
State/province [340]
0
0
Belgorod
Query!
Country [341]
0
0
Russian Federation
Query!
State/province [341]
0
0
Chelyabinsk
Query!
Country [342]
0
0
Russian Federation
Query!
State/province [342]
0
0
Ekaterinburg
Query!
Country [343]
0
0
Russian Federation
Query!
State/province [343]
0
0
Irkutsk
Query!
Country [344]
0
0
Russian Federation
Query!
State/province [344]
0
0
Izhevsk
Query!
Country [345]
0
0
Russian Federation
Query!
State/province [345]
0
0
Kazan
Query!
Country [346]
0
0
Russian Federation
Query!
State/province [346]
0
0
Moscow
Query!
Country [347]
0
0
Russian Federation
Query!
State/province [347]
0
0
Nizhnii Novgorod
Query!
Country [348]
0
0
Russian Federation
Query!
State/province [348]
0
0
Nizhny Novgorod
Query!
Country [349]
0
0
Russian Federation
Query!
State/province [349]
0
0
Novosibirsk
Query!
Country [350]
0
0
Russian Federation
Query!
State/province [350]
0
0
Omsk
Query!
Country [351]
0
0
Russian Federation
Query!
State/province [351]
0
0
Perm
Query!
Country [352]
0
0
Russian Federation
Query!
State/province [352]
0
0
Saint Petersburg
Query!
Country [353]
0
0
Russian Federation
Query!
State/province [353]
0
0
Saint-Petersburg
Query!
Country [354]
0
0
Russian Federation
Query!
State/province [354]
0
0
Saratov
Query!
Country [355]
0
0
Russian Federation
Query!
State/province [355]
0
0
Ufa
Query!
Country [356]
0
0
Russian Federation
Query!
State/province [356]
0
0
Voronezh
Query!
Country [357]
0
0
Russian Federation
Query!
State/province [357]
0
0
Yaroslavl
Query!
Country [358]
0
0
Slovakia
Query!
State/province [358]
0
0
Levoca
Query!
Country [359]
0
0
Slovakia
Query!
State/province [359]
0
0
Martin
Query!
Country [360]
0
0
Slovakia
Query!
State/province [360]
0
0
Nitra
Query!
Country [361]
0
0
Slovakia
Query!
State/province [361]
0
0
Spisska Nova Ves
Query!
Country [362]
0
0
Slovakia
Query!
State/province [362]
0
0
Trnava
Query!
Country [363]
0
0
Slovakia
Query!
State/province [363]
0
0
Zilina
Query!
Country [364]
0
0
Spain
Query!
State/province [364]
0
0
Albacete
Query!
Country [365]
0
0
Spain
Query!
State/province [365]
0
0
Badalona(Barcelona)
Query!
Country [366]
0
0
Spain
Query!
State/province [366]
0
0
Barcelona
Query!
Country [367]
0
0
Spain
Query!
State/province [367]
0
0
Gerona
Query!
Country [368]
0
0
Spain
Query!
State/province [368]
0
0
Lleida
Query!
Country [369]
0
0
Spain
Query!
State/province [369]
0
0
Madrid
Query!
Country [370]
0
0
Spain
Query!
State/province [370]
0
0
Pamplona
Query!
Country [371]
0
0
Spain
Query!
State/province [371]
0
0
Santiago(A Coruña)
Query!
Country [372]
0
0
Spain
Query!
State/province [372]
0
0
Sevilla
Query!
Country [373]
0
0
Spain
Query!
State/province [373]
0
0
Valencia
Query!
Country [374]
0
0
Spain
Query!
State/province [374]
0
0
Valladolid
Query!
Country [375]
0
0
Sweden
Query!
State/province [375]
0
0
Falun
Query!
Country [376]
0
0
Sweden
Query!
State/province [376]
0
0
Göteborg
Query!
Country [377]
0
0
Sweden
Query!
State/province [377]
0
0
Halmstad
Query!
Country [378]
0
0
Sweden
Query!
State/province [378]
0
0
Karlstad
Query!
Country [379]
0
0
Sweden
Query!
State/province [379]
0
0
Lidköping
Query!
Country [380]
0
0
Sweden
Query!
State/province [380]
0
0
Linköping
Query!
Country [381]
0
0
Sweden
Query!
State/province [381]
0
0
Malmö
Query!
Country [382]
0
0
Sweden
Query!
State/province [382]
0
0
Mora
Query!
Country [383]
0
0
Sweden
Query!
State/province [383]
0
0
Norrköping
Query!
Country [384]
0
0
Sweden
Query!
State/province [384]
0
0
Stockholm
Query!
Country [385]
0
0
Sweden
Query!
State/province [385]
0
0
Uppsala
Query!
Country [386]
0
0
Sweden
Query!
State/province [386]
0
0
Västerås
Query!
Country [387]
0
0
Sweden
Query!
State/province [387]
0
0
Östersund
Query!
Country [388]
0
0
Switzerland
Query!
State/province [388]
0
0
Aarau
Query!
Country [389]
0
0
Switzerland
Query!
State/province [389]
0
0
Basel
Query!
Country [390]
0
0
Switzerland
Query!
State/province [390]
0
0
Bern
Query!
Country [391]
0
0
Switzerland
Query!
State/province [391]
0
0
Chur
Query!
Country [392]
0
0
Switzerland
Query!
State/province [392]
0
0
Genève 14
Query!
Country [393]
0
0
Switzerland
Query!
State/province [393]
0
0
Lausanne
Query!
Country [394]
0
0
Switzerland
Query!
State/province [394]
0
0
Lugano
Query!
Country [395]
0
0
Switzerland
Query!
State/province [395]
0
0
St. Gallen
Query!
Country [396]
0
0
Switzerland
Query!
State/province [396]
0
0
Villars-sur-Glâne
Query!
Country [397]
0
0
Switzerland
Query!
State/province [397]
0
0
Zürich
Query!
Country [398]
0
0
Taiwan
Query!
State/province [398]
0
0
Changhua City
Query!
Country [399]
0
0
Taiwan
Query!
State/province [399]
0
0
Chiayi
Query!
Country [400]
0
0
Taiwan
Query!
State/province [400]
0
0
Kaohsiung
Query!
Country [401]
0
0
Taiwan
Query!
State/province [401]
0
0
New Taipei
Query!
Country [402]
0
0
Taiwan
Query!
State/province [402]
0
0
Taichung
Query!
Country [403]
0
0
Taiwan
Query!
State/province [403]
0
0
Tainan
Query!
Country [404]
0
0
Taiwan
Query!
State/province [404]
0
0
Taipei
Query!
Country [405]
0
0
Taiwan
Query!
State/province [405]
0
0
Taoyuan Hsien
Query!
Country [406]
0
0
Thailand
Query!
State/province [406]
0
0
Bangkok
Query!
Country [407]
0
0
Thailand
Query!
State/province [407]
0
0
Chonburi
Query!
Country [408]
0
0
Thailand
Query!
State/province [408]
0
0
Khon Kaen
Query!
Country [409]
0
0
Thailand
Query!
State/province [409]
0
0
Muang
Query!
Country [410]
0
0
Thailand
Query!
State/province [410]
0
0
Patumthani
Query!
Country [411]
0
0
Thailand
Query!
State/province [411]
0
0
Rajthevi
Query!
Country [412]
0
0
Thailand
Query!
State/province [412]
0
0
Ratchathewi
Query!
Country [413]
0
0
Turkey
Query!
State/province [413]
0
0
Ankara
Query!
Country [414]
0
0
Turkey
Query!
State/province [414]
0
0
Antalya
Query!
Country [415]
0
0
Turkey
Query!
State/province [415]
0
0
Eskisehir
Query!
Country [416]
0
0
Turkey
Query!
State/province [416]
0
0
Istanbul
Query!
Country [417]
0
0
Turkey
Query!
State/province [417]
0
0
Izmir
Query!
Country [418]
0
0
Turkey
Query!
State/province [418]
0
0
Konya
Query!
Country [419]
0
0
Ukraine
Query!
State/province [419]
0
0
Ivano-Frankivsk
Query!
Country [420]
0
0
Ukraine
Query!
State/province [420]
0
0
Kharkiv
Query!
Country [421]
0
0
Ukraine
Query!
State/province [421]
0
0
Kyiv
Query!
Country [422]
0
0
Ukraine
Query!
State/province [422]
0
0
Lutsk
Query!
Country [423]
0
0
Ukraine
Query!
State/province [423]
0
0
Lviv
Query!
Country [424]
0
0
Ukraine
Query!
State/province [424]
0
0
Uzhgorod
Query!
Country [425]
0
0
Ukraine
Query!
State/province [425]
0
0
Vinnytsia
Query!
Country [426]
0
0
Ukraine
Query!
State/province [426]
0
0
Zaporizhzhya
Query!
Country [427]
0
0
Vietnam
Query!
State/province [427]
0
0
Hanoi
Query!
Country [428]
0
0
Vietnam
Query!
State/province [428]
0
0
Ho Chi Minh City
Query!
Country [429]
0
0
Vietnam
Query!
State/province [429]
0
0
Hochiminh
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
AstraZeneca
Query!
Address
Query!
Country
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
The primary objective of the study is to compare the effect of 90-day treatment with ticagrelor (180 mg \[two 90 mg tablets\] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-aspirin (300 mg \[three 100 mg tablets\] loading dose on Day 1 followed by 100 mg once daily maintenance dose for the remainder of the study) for the prevention of major vascular events (composite of stroke, myocardial infarction \[MI\], and death) in patients with acute ischaemic stroke or transient ischaemic attack (TIA).
Query!
Trial website
https://clinicaltrials.gov/study/NCT01994720
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Trial related presentations / publications
Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10. Evans SR, Knutsson M, Amarenco P, Albers GW, Bath PM, Denison H, Ladenvall P, Jonasson J, Easton JD, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC. Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clin Trials. 2020 Dec;17(6):617-626. doi: 10.1177/1740774520941441. Epub 2020 Jul 15. Cucchiara B, George DK, Kasner SE, Knutsson M, Denison H, Ladenvall P, Amarenco P, Johnston SC. Disability after minor stroke and TIA: A secondary analysis of the SOCRATES trial. Neurology. 2019 Aug 13;93(7):e708-e716. doi: 10.1212/WNL.0000000000007936. Epub 2019 Jul 11. Easton JD, Denison H, Evans SR, Knutsson M, Amarenco P, Albers GW, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC; SOCRATES Steering Committee and Investigators. Estimated treatment effect of ticagrelor versus aspirin by investigator-assessed events compared with judgement by an independent event adjudication committee in the SOCRATES trial. Int J Stroke. 2019 Dec;14(9):908-914. doi: 10.1177/1747493019851282. Epub 2019 May 15. Molina CA, Johnston SC, Ladenvall P, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Knutsson M, Minematsu K, Rother J, Wang Y, Wong KSL; SOCRATES Steering Committee and Investigators. Time to Loading Dose and Risk of Recurrent Events in the SOCRATES Trial. Stroke. 2019 Mar;50(3):675-682. doi: 10.1161/STROKEAHA.118.022675. Erratum In: Stroke. 2019 Apr;50(4):e118. doi: 10.1161/STR.0000000000000186. Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18. Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. Stroke. 2017 Sep;48(9):2480-2487. doi: 10.1161/STROKEAHA.117.017217. Epub 2017 Jul 18. Easton JD, Aunes M, Albers GW, Amarenco P, Bokelund-Singh S, Denison H, Evans SR, Held P, Jahreskog M, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Circulation. 2017 Sep 5;136(10):907-916. doi: 10.1161/CIRCULATIONAHA.117.028566. Epub 2017 Jun 27. Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol. 2017 Apr;16(4):301-310. doi: 10.1016/S1474-4422(17)30038-8. Epub 2017 Feb 23. Wang Y, Minematsu K, Wong KS, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Molina CA, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Stroke. 2017 Jan;48(1):167-173. doi: 10.1161/STROKEAHA.116.014891. Epub 2016 Nov 29. Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10. Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Jul 7;375(1):35-43. doi: 10.1056/NEJMoa1603060. Epub 2016 May 10.
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