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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01225562
Registration number
NCT01225562
Ethics application status
Date submitted
9/07/2010
Date registered
21/10/2010
Date last updated
25/01/2016
Titles & IDs
Public title
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
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Scientific title
A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction
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Secondary ID [1]
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0
2009-017242-30
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Secondary ID [2]
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D5132C00001
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Universal Trial Number (UTN)
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Trial acronym
PEGASUS
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Myocardial Infarction
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0
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Cardiovascular Death
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0
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Atherothrombosis
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0
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Stroke
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Condition category
Condition code
Cardiovascular
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0
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0
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Coronary heart disease
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Cardiovascular
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0
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Other cardiovascular diseases
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Cardiovascular
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0
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Diseases of the vasculature and circulation including the lymphatic system
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Blood
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Clotting disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Ticagrelor 90 mg
Treatment: Drugs - Ticagrelor 60 mg
Treatment: Drugs - Ticagrelor Placebo
Experimental: 1 - Oral Treatment
Experimental: 2 - Oral Treatment
Placebo comparator: 3 - Oral Treatment
Treatment: Drugs: Ticagrelor 90 mg
Oral dose twice a day
Treatment: Drugs: Ticagrelor 60 mg
Oral dose twice a day
Treatment: Drugs: Ticagrelor Placebo
Oral dose twice a day
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Intervention code [1]
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Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization
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Assessment method [1]
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Participants with CV death, MI or Stroke. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death, MI or stroke within 3 years from randomization
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Timepoint [1]
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Randomization up to 47 months
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Primary outcome [2]
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Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients
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Assessment method [2]
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A Thrombolysis in Myocardial Infarction (TIMI) study group major bleeding is defined as any fatal bleeding (leading directly to death within 7 days), any intrcranial bleeding or any clinically overt signs of haemorrhage associated with a drop in Haemoglobin of \>= 5g/dL. Events were adjudicated by a clinical events committee. Censoring ocurrs at 7 days following last dose of study drug. The Kaplan-Meier estimate reports the percentage of patients who experienced a TIMI Major bleeding within 3 years from first dose of study drug
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Timepoint [2]
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First dosing up to 48 months
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Secondary outcome [1]
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Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization
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Assessment method [1]
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Participants with CV death. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death within 3 years from randomization
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Timepoint [1]
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Randomization up to 47 months
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Secondary outcome [2]
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Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization
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Assessment method [2]
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Participants with death from any cause. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent or the last time point the particapant was known to be alive. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who died from any cause within 3 years from randomization
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Timepoint [2]
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Randomization up to 47 months
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Eligibility
Key inclusion criteria
* Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age = 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
* Females of child-bearing potential must have a negative pregnancy test at enrollment
* Persons who are currently taking aspirin between 75 and 150 mg once daily
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Minimum age
50
Years
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Maximum age
130
Years
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
* Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
* Persons with known bleeding disorders
* Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
* Persons with a history of ischemic stroke
* Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
* Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
* Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
* Persons with known severe liver disease
* Persons with kidney failure requiring dialysis
* Persons with life expectancy < 1 year
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Study design
Purpose of the study
Prevention
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/10/2010
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
1/12/2014
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Sample size
Target
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Accrual to date
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Final
21379
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Recruitment in Australia
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Research Site - Adelaide
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- Adelaide
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- Ashford
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- Auchenflower
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- Ballarat
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- Clayton
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- East St Kilda
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- Elizabeth Vale
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- Epping
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- Geelong
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- Greenslopes
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- Herston
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- Kingswood
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- Kogorah
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- Launceston
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- New Lambton Heights
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- Richmond
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- St Leonards
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- Wollongong
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- Woodville
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- Woolloongabba
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Recruitment outside Australia
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Query!
Country [93]
0
0
Belgium
Query!
State/province [93]
0
0
Ottignies
Query!
Country [94]
0
0
Belgium
Query!
State/province [94]
0
0
Roeselare
Query!
Country [95]
0
0
Belgium
Query!
State/province [95]
0
0
Tienen
Query!
Country [96]
0
0
Belgium
Query!
State/province [96]
0
0
Turnhout
Query!
Country [97]
0
0
Belgium
Query!
State/province [97]
0
0
Yvoir
Query!
Country [98]
0
0
Belgium
Query!
State/province [98]
0
0
Zottegem
Query!
Country [99]
0
0
Brazil
Query!
State/province [99]
0
0
Aracaju
Query!
Country [100]
0
0
Brazil
Query!
State/province [100]
0
0
Belo Horizonte
Query!
Country [101]
0
0
Brazil
Query!
State/province [101]
0
0
Blumenau
Query!
Country [102]
0
0
Brazil
Query!
State/province [102]
0
0
Brasília
Query!
Country [103]
0
0
Brazil
Query!
State/province [103]
0
0
Campina Grande do Sul
Query!
Country [104]
0
0
Brazil
Query!
State/province [104]
0
0
Campinas
Query!
Country [105]
0
0
Brazil
Query!
State/province [105]
0
0
Campo Grande
Query!
Country [106]
0
0
Brazil
Query!
State/province [106]
0
0
Curitiba
Query!
Country [107]
0
0
Brazil
Query!
State/province [107]
0
0
Goiânia
Query!
Country [108]
0
0
Brazil
Query!
State/province [108]
0
0
Maceio
Query!
Country [109]
0
0
Brazil
Query!
State/province [109]
0
0
Marilia
Query!
Country [110]
0
0
Brazil
Query!
State/province [110]
0
0
Porto Alegre
Query!
Country [111]
0
0
Brazil
Query!
State/province [111]
0
0
Ribeirão Preto
Query!
Country [112]
0
0
Brazil
Query!
State/province [112]
0
0
Rio de Janeiro
Query!
Country [113]
0
0
Brazil
Query!
State/province [113]
0
0
S.J.Rio Preto
Query!
Country [114]
0
0
Brazil
Query!
State/province [114]
0
0
Salvador
Query!
Country [115]
0
0
Brazil
Query!
State/province [115]
0
0
São José do Rio Preto
Query!
Country [116]
0
0
Brazil
Query!
State/province [116]
0
0
São Paulo
Query!
Country [117]
0
0
Brazil
Query!
State/province [117]
0
0
Uberlândia
Query!
Country [118]
0
0
Brazil
Query!
State/province [118]
0
0
Votuporanga
Query!
Country [119]
0
0
Bulgaria
Query!
State/province [119]
0
0
Dimitrovgrad
Query!
Country [120]
0
0
Bulgaria
Query!
State/province [120]
0
0
Gotse Delchev
Query!
Country [121]
0
0
Bulgaria
Query!
State/province [121]
0
0
Pernik
Query!
Country [122]
0
0
Bulgaria
Query!
State/province [122]
0
0
Pleven
Query!
Country [123]
0
0
Bulgaria
Query!
State/province [123]
0
0
Plovdiv
Query!
Country [124]
0
0
Bulgaria
Query!
State/province [124]
0
0
Razlog
Query!
Country [125]
0
0
Bulgaria
Query!
State/province [125]
0
0
Ruse
Query!
Country [126]
0
0
Bulgaria
Query!
State/province [126]
0
0
Sevlievo
Query!
Country [127]
0
0
Bulgaria
Query!
State/province [127]
0
0
Sofia
Query!
Country [128]
0
0
Bulgaria
Query!
State/province [128]
0
0
Varna
Query!
Country [129]
0
0
Bulgaria
Query!
State/province [129]
0
0
Veliko Tarnovo
Query!
Country [130]
0
0
Canada
Query!
State/province [130]
0
0
Alberta
Query!
Country [131]
0
0
Canada
Query!
State/province [131]
0
0
British Columbia
Query!
Country [132]
0
0
Canada
Query!
State/province [132]
0
0
New Brunswick
Query!
Country [133]
0
0
Canada
Query!
State/province [133]
0
0
Newfoundland and Labrador
Query!
Country [134]
0
0
Canada
Query!
State/province [134]
0
0
Nova Scotia
Query!
Country [135]
0
0
Canada
Query!
State/province [135]
0
0
Ontario
Query!
Country [136]
0
0
Canada
Query!
State/province [136]
0
0
Quebec
Query!
Country [137]
0
0
Canada
Query!
State/province [137]
0
0
Saskatchewan
Query!
Country [138]
0
0
Chile
Query!
State/province [138]
0
0
Concepcion
Query!
Country [139]
0
0
Chile
Query!
State/province [139]
0
0
Osorno
Query!
Country [140]
0
0
Chile
Query!
State/province [140]
0
0
Rancagua
Query!
Country [141]
0
0
Chile
Query!
State/province [141]
0
0
Santiago Centro
Query!
Country [142]
0
0
Chile
Query!
State/province [142]
0
0
Santiago
Query!
Country [143]
0
0
Chile
Query!
State/province [143]
0
0
Temuco
Query!
Country [144]
0
0
Chile
Query!
State/province [144]
0
0
Vina del Mar
Query!
Country [145]
0
0
China
Query!
State/province [145]
0
0
Beijing
Query!
Country [146]
0
0
China
Query!
State/province [146]
0
0
Changsha
Query!
Country [147]
0
0
China
Query!
State/province [147]
0
0
Chongqing
Query!
Country [148]
0
0
China
Query!
State/province [148]
0
0
Guang Zhou
Query!
Country [149]
0
0
China
Query!
State/province [149]
0
0
Guangzhou
Query!
Country [150]
0
0
China
Query!
State/province [150]
0
0
Hang Zhou
Query!
Country [151]
0
0
China
Query!
State/province [151]
0
0
Lanzhou
Query!
Country [152]
0
0
China
Query!
State/province [152]
0
0
Nanjing
Query!
Country [153]
0
0
China
Query!
State/province [153]
0
0
Shanghai
Query!
Country [154]
0
0
China
Query!
State/province [154]
0
0
Shengyang
Query!
Country [155]
0
0
China
Query!
State/province [155]
0
0
Shenyang
Query!
Country [156]
0
0
China
Query!
State/province [156]
0
0
Taiyuan
Query!
Country [157]
0
0
China
Query!
State/province [157]
0
0
Wuhan
Query!
Country [158]
0
0
China
Query!
State/province [158]
0
0
Xi'an
Query!
Country [159]
0
0
Colombia
Query!
State/province [159]
0
0
Armenia
Query!
Country [160]
0
0
Colombia
Query!
State/province [160]
0
0
Barranquilla
Query!
Country [161]
0
0
Colombia
Query!
State/province [161]
0
0
Bogota
Query!
Country [162]
0
0
Colombia
Query!
State/province [162]
0
0
Bogotá D.C.
Query!
Country [163]
0
0
Colombia
Query!
State/province [163]
0
0
Bucaramanga
Query!
Country [164]
0
0
Colombia
Query!
State/province [164]
0
0
Cali
Query!
Country [165]
0
0
Colombia
Query!
State/province [165]
0
0
Cartagena
Query!
Country [166]
0
0
Colombia
Query!
State/province [166]
0
0
Manizales
Query!
Country [167]
0
0
Colombia
Query!
State/province [167]
0
0
Medellin
Query!
Country [168]
0
0
Colombia
Query!
State/province [168]
0
0
Medellín
Query!
Country [169]
0
0
Colombia
Query!
State/province [169]
0
0
Medillin
Query!
Country [170]
0
0
Czech Republic
Query!
State/province [170]
0
0
Brno
Query!
Country [171]
0
0
Czech Republic
Query!
State/province [171]
0
0
Caslav
Query!
Country [172]
0
0
Czech Republic
Query!
State/province [172]
0
0
Ceska Lipa
Query!
Country [173]
0
0
Czech Republic
Query!
State/province [173]
0
0
Cesky Krumlov
Query!
Country [174]
0
0
Czech Republic
Query!
State/province [174]
0
0
Chomutov
Query!
Country [175]
0
0
Czech Republic
Query!
State/province [175]
0
0
Havirov
Query!
Country [176]
0
0
Czech Republic
Query!
State/province [176]
0
0
Kromeriz
Query!
Country [177]
0
0
Czech Republic
Query!
State/province [177]
0
0
Kyjov
Query!
Country [178]
0
0
Czech Republic
Query!
State/province [178]
0
0
Liberec
Query!
Country [179]
0
0
Czech Republic
Query!
State/province [179]
0
0
Marianske Lazne
Query!
Country [180]
0
0
Czech Republic
Query!
State/province [180]
0
0
Ostrava-Poruba
Query!
Country [181]
0
0
Czech Republic
Query!
State/province [181]
0
0
Ostrava-Zabreh
Query!
Country [182]
0
0
Czech Republic
Query!
State/province [182]
0
0
Ostrava
Query!
Country [183]
0
0
Czech Republic
Query!
State/province [183]
0
0
Pelhrimov
Query!
Country [184]
0
0
Czech Republic
Query!
State/province [184]
0
0
Praha 2
Query!
Country [185]
0
0
Czech Republic
Query!
State/province [185]
0
0
Praha 5
Query!
Country [186]
0
0
Czech Republic
Query!
State/province [186]
0
0
Praha 6
Query!
Country [187]
0
0
Czech Republic
Query!
State/province [187]
0
0
Pribram
Query!
Country [188]
0
0
Czech Republic
Query!
State/province [188]
0
0
Slany
Query!
Country [189]
0
0
Czech Republic
Query!
State/province [189]
0
0
Teplice
Query!
Country [190]
0
0
Czech Republic
Query!
State/province [190]
0
0
Usti nad Labem
Query!
Country [191]
0
0
Czech Republic
Query!
State/province [191]
0
0
Usti nad Orlici
Query!
Country [192]
0
0
Czech Republic
Query!
State/province [192]
0
0
Znojmo
Query!
Country [193]
0
0
France
Query!
State/province [193]
0
0
ABBEVILLE cedex
Query!
Country [194]
0
0
France
Query!
State/province [194]
0
0
Albi
Query!
Country [195]
0
0
France
Query!
State/province [195]
0
0
ANGERS Cedex 9
Query!
Country [196]
0
0
France
Query!
State/province [196]
0
0
Angers
Query!
Country [197]
0
0
France
Query!
State/province [197]
0
0
Avignon Cedex
Query!
Country [198]
0
0
France
Query!
State/province [198]
0
0
Bayonne
Query!
Country [199]
0
0
France
Query!
State/province [199]
0
0
Cannes
Query!
Country [200]
0
0
France
Query!
State/province [200]
0
0
Creteil
Query!
Country [201]
0
0
France
Query!
State/province [201]
0
0
Dijon
Query!
Country [202]
0
0
France
Query!
State/province [202]
0
0
Jossigny
Query!
Country [203]
0
0
France
Query!
State/province [203]
0
0
La Rochelle Cedex
Query!
Country [204]
0
0
France
Query!
State/province [204]
0
0
Le Chesnay
Query!
Country [205]
0
0
France
Query!
State/province [205]
0
0
Le Coudray Cedex
Query!
Country [206]
0
0
France
Query!
State/province [206]
0
0
Limoges Cedex
Query!
Country [207]
0
0
France
Query!
State/province [207]
0
0
MARSEILLE Cedex 5
Query!
Country [208]
0
0
France
Query!
State/province [208]
0
0
Metz Cedex 1
Query!
Country [209]
0
0
France
Query!
State/province [209]
0
0
NICE Cedex 01
Query!
Country [210]
0
0
France
Query!
State/province [210]
0
0
NIMES Cedex 9
Query!
Country [211]
0
0
France
Query!
State/province [211]
0
0
Orléans Cedex 2
Query!
Country [212]
0
0
France
Query!
State/province [212]
0
0
Paris
Query!
Country [213]
0
0
France
Query!
State/province [213]
0
0
Pessac
Query!
Country [214]
0
0
France
Query!
State/province [214]
0
0
Poitiers
Query!
Country [215]
0
0
France
Query!
State/province [215]
0
0
Toulouse Cedex
Query!
Country [216]
0
0
France
Query!
State/province [216]
0
0
TOURCOING cedex
Query!
Country [217]
0
0
Germany
Query!
State/province [217]
0
0
Bad Krozingen
Query!
Country [218]
0
0
Germany
Query!
State/province [218]
0
0
Bad Mergentheim
Query!
Country [219]
0
0
Germany
Query!
State/province [219]
0
0
Bad Nauheim
Query!
Country [220]
0
0
Germany
Query!
State/province [220]
0
0
Berlin
Query!
Country [221]
0
0
Germany
Query!
State/province [221]
0
0
Bielefeld
Query!
Country [222]
0
0
Germany
Query!
State/province [222]
0
0
Coburg
Query!
Country [223]
0
0
Germany
Query!
State/province [223]
0
0
Deggingen
Query!
Country [224]
0
0
Germany
Query!
State/province [224]
0
0
Dortmund
Query!
Country [225]
0
0
Germany
Query!
State/province [225]
0
0
Dresden
Query!
Country [226]
0
0
Germany
Query!
State/province [226]
0
0
Essen
Query!
Country [227]
0
0
Germany
Query!
State/province [227]
0
0
Esslingen
Query!
Country [228]
0
0
Germany
Query!
State/province [228]
0
0
Frankfurt
Query!
Country [229]
0
0
Germany
Query!
State/province [229]
0
0
Hamburg
Query!
Country [230]
0
0
Germany
Query!
State/province [230]
0
0
Heidelberg
Query!
Country [231]
0
0
Germany
Query!
State/province [231]
0
0
Kassel
Query!
Country [232]
0
0
Germany
Query!
State/province [232]
0
0
Kiel
Query!
Country [233]
0
0
Germany
Query!
State/province [233]
0
0
Leipzig
Query!
Country [234]
0
0
Germany
Query!
State/province [234]
0
0
Limburg
Query!
Country [235]
0
0
Germany
Query!
State/province [235]
0
0
Ludwigshafen
Query!
Country [236]
0
0
Germany
Query!
State/province [236]
0
0
Lübeck
Query!
Country [237]
0
0
Germany
Query!
State/province [237]
0
0
Mainz
Query!
Country [238]
0
0
Germany
Query!
State/province [238]
0
0
Mönchengladbach
Query!
Country [239]
0
0
Germany
Query!
State/province [239]
0
0
Ulm
Query!
Country [240]
0
0
Germany
Query!
State/province [240]
0
0
Warendorf
Query!
Country [241]
0
0
Germany
Query!
State/province [241]
0
0
Witten
Query!
Country [242]
0
0
Hungary
Query!
State/province [242]
0
0
Ballasagyarmat
Query!
Country [243]
0
0
Hungary
Query!
State/province [243]
0
0
Budapest
Query!
Country [244]
0
0
Hungary
Query!
State/province [244]
0
0
Békéscsaba
Query!
Country [245]
0
0
Hungary
Query!
State/province [245]
0
0
Cegléd
Query!
Country [246]
0
0
Hungary
Query!
State/province [246]
0
0
Debrecen
Query!
Country [247]
0
0
Hungary
Query!
State/province [247]
0
0
Eger
Query!
Country [248]
0
0
Hungary
Query!
State/province [248]
0
0
Gyula
Query!
Country [249]
0
0
Hungary
Query!
State/province [249]
0
0
Kalocsa
Query!
Country [250]
0
0
Hungary
Query!
State/province [250]
0
0
Kecskemét
Query!
Country [251]
0
0
Hungary
Query!
State/province [251]
0
0
Mosonmagyaróvár
Query!
Country [252]
0
0
Hungary
Query!
State/province [252]
0
0
Nyíregyháza
Query!
Country [253]
0
0
Hungary
Query!
State/province [253]
0
0
Pécs
Query!
Country [254]
0
0
Hungary
Query!
State/province [254]
0
0
Sopron
Query!
Country [255]
0
0
Hungary
Query!
State/province [255]
0
0
Szeged
Query!
Country [256]
0
0
Hungary
Query!
State/province [256]
0
0
Szekszárd
Query!
Country [257]
0
0
Hungary
Query!
State/province [257]
0
0
Szolnok
Query!
Country [258]
0
0
Hungary
Query!
State/province [258]
0
0
Székesfehérvár
Query!
Country [259]
0
0
Hungary
Query!
State/province [259]
0
0
Zalaegerszeg
Query!
Country [260]
0
0
Italy
Query!
State/province [260]
0
0
Albano Laziale
Query!
Country [261]
0
0
Italy
Query!
State/province [261]
0
0
Bari
Query!
Country [262]
0
0
Italy
Query!
State/province [262]
0
0
Benevento
Query!
Country [263]
0
0
Italy
Query!
State/province [263]
0
0
Brescia
Query!
Country [264]
0
0
Italy
Query!
State/province [264]
0
0
Carpi
Query!
Country [265]
0
0
Italy
Query!
State/province [265]
0
0
Catania
Query!
Country [266]
0
0
Italy
Query!
State/province [266]
0
0
Genova
Query!
Country [267]
0
0
Italy
Query!
State/province [267]
0
0
Legnano
Query!
Country [268]
0
0
Italy
Query!
State/province [268]
0
0
Lucca
Query!
Country [269]
0
0
Italy
Query!
State/province [269]
0
0
Massa
Query!
Country [270]
0
0
Italy
Query!
State/province [270]
0
0
Milano
Query!
Country [271]
0
0
Italy
Query!
State/province [271]
0
0
Napoli
Query!
Country [272]
0
0
Italy
Query!
State/province [272]
0
0
Osio Sotto frazione di Zingoni
Query!
Country [273]
0
0
Italy
Query!
State/province [273]
0
0
Parma
Query!
Country [274]
0
0
Italy
Query!
State/province [274]
0
0
Pavia
Query!
Country [275]
0
0
Italy
Query!
State/province [275]
0
0
Perugia
Query!
Country [276]
0
0
Italy
Query!
State/province [276]
0
0
Pescara
Query!
Country [277]
0
0
Italy
Query!
State/province [277]
0
0
Pisa
Query!
Country [278]
0
0
Italy
Query!
State/province [278]
0
0
Reggio Emilia
Query!
Country [279]
0
0
Italy
Query!
State/province [279]
0
0
Roma
Query!
Country [280]
0
0
Italy
Query!
State/province [280]
0
0
Rozzano
Query!
Country [281]
0
0
Italy
Query!
State/province [281]
0
0
S Maria Capua Vetere
Query!
Country [282]
0
0
Italy
Query!
State/province [282]
0
0
San Remo
Query!
Country [283]
0
0
Italy
Query!
State/province [283]
0
0
Sassari
Query!
Country [284]
0
0
Italy
Query!
State/province [284]
0
0
Sessa Aurunca
Query!
Country [285]
0
0
Italy
Query!
State/province [285]
0
0
Siena
Query!
Country [286]
0
0
Italy
Query!
State/province [286]
0
0
Sorrento NA
Query!
Country [287]
0
0
Italy
Query!
State/province [287]
0
0
Vimercate
Query!
Country [288]
0
0
Japan
Query!
State/province [288]
0
0
Akishima-shi
Query!
Country [289]
0
0
Japan
Query!
State/province [289]
0
0
Amagasaki-shi
Query!
Country [290]
0
0
Japan
Query!
State/province [290]
0
0
Beppu-shi
Query!
Country [291]
0
0
Japan
Query!
State/province [291]
0
0
Chuo-ku
Query!
Country [292]
0
0
Japan
Query!
State/province [292]
0
0
Daito-shi
Query!
Country [293]
0
0
Japan
Query!
State/province [293]
0
0
Fukui-shi
Query!
Country [294]
0
0
Japan
Query!
State/province [294]
0
0
Funabashi-shi
Query!
Country [295]
0
0
Japan
Query!
State/province [295]
0
0
Gifu-shi
Query!
Country [296]
0
0
Japan
Query!
State/province [296]
0
0
Hamamatsu-shi
Query!
Country [297]
0
0
Japan
Query!
State/province [297]
0
0
Himeji-shi
Query!
Country [298]
0
0
Japan
Query!
State/province [298]
0
0
Imabari-shi
Query!
Country [299]
0
0
Japan
Query!
State/province [299]
0
0
Isehara-shi
Query!
Country [300]
0
0
Japan
Query!
State/province [300]
0
0
Kamogawa-shi
Query!
Country [301]
0
0
Japan
Query!
State/province [301]
0
0
Kanazawa-shi
Query!
Country [302]
0
0
Japan
Query!
State/province [302]
0
0
Kawachinagano-shi
Query!
Country [303]
0
0
Japan
Query!
State/province [303]
0
0
Kisarazu-shi
Query!
Country [304]
0
0
Japan
Query!
State/province [304]
0
0
Komatsushima-shi
Query!
Country [305]
0
0
Japan
Query!
State/province [305]
0
0
Koriyama-shi
Query!
Country [306]
0
0
Japan
Query!
State/province [306]
0
0
Kumamoto-shi
Query!
Country [307]
0
0
Japan
Query!
State/province [307]
0
0
Kure-shi
Query!
Country [308]
0
0
Japan
Query!
State/province [308]
0
0
Kusatsu-shi
Query!
Country [309]
0
0
Japan
Query!
State/province [309]
0
0
Kyoto-shi
Query!
Country [310]
0
0
Japan
Query!
State/province [310]
0
0
Maebashi-shi
Query!
Country [311]
0
0
Japan
Query!
State/province [311]
0
0
Matsue-shi
Query!
Country [312]
0
0
Japan
Query!
State/province [312]
0
0
Matsumoto-shi
Query!
Country [313]
0
0
Japan
Query!
State/province [313]
0
0
Matsuyama-shi
Query!
Country [314]
0
0
Japan
Query!
State/province [314]
0
0
Meguro-ku
Query!
Country [315]
0
0
Japan
Query!
State/province [315]
0
0
Miyazaki-shi
Query!
Country [316]
0
0
Japan
Query!
State/province [316]
0
0
Osaka-shi
Query!
Country [317]
0
0
Japan
Query!
State/province [317]
0
0
Saga-shi
Query!
Country [318]
0
0
Japan
Query!
State/province [318]
0
0
Sagamihara-shi
Query!
Country [319]
0
0
Japan
Query!
State/province [319]
0
0
Saitama-shi
Query!
Country [320]
0
0
Japan
Query!
State/province [320]
0
0
Sakai-shi
Query!
Country [321]
0
0
Japan
Query!
State/province [321]
0
0
Sakaide-shi
Query!
Country [322]
0
0
Japan
Query!
State/province [322]
0
0
Sapporo-shi
Query!
Country [323]
0
0
Japan
Query!
State/province [323]
0
0
Sayama-shi
Query!
Country [324]
0
0
Japan
Query!
State/province [324]
0
0
Shimada-shi
Query!
Country [325]
0
0
Japan
Query!
State/province [325]
0
0
Shinagawa-ku
Query!
Country [326]
0
0
Japan
Query!
State/province [326]
0
0
Shizuoka-shi
Query!
Country [327]
0
0
Japan
Query!
State/province [327]
0
0
Suwa-shi
Query!
Country [328]
0
0
Japan
Query!
State/province [328]
0
0
Takarazuka-shi
Query!
Country [329]
0
0
Japan
Query!
State/province [329]
0
0
Takasaki-shi
Query!
Country [330]
0
0
Japan
Query!
State/province [330]
0
0
Takatsuki-shi
Query!
Country [331]
0
0
Japan
Query!
State/province [331]
0
0
Tomakomai-shi
Query!
Country [332]
0
0
Japan
Query!
State/province [332]
0
0
Toyonaka-shi
Query!
Country [333]
0
0
Japan
Query!
State/province [333]
0
0
Ueda-shi
Query!
Country [334]
0
0
Japan
Query!
State/province [334]
0
0
Wakayama-shi
Query!
Country [335]
0
0
Japan
Query!
State/province [335]
0
0
Wako-shi
Query!
Country [336]
0
0
Japan
Query!
State/province [336]
0
0
Yatsushiro-shi
Query!
Country [337]
0
0
Japan
Query!
State/province [337]
0
0
Yokohama-shi
Query!
Country [338]
0
0
Korea, Republic of
Query!
State/province [338]
0
0
Bucheon-si
Query!
Country [339]
0
0
Korea, Republic of
Query!
State/province [339]
0
0
Busan
Query!
Country [340]
0
0
Korea, Republic of
Query!
State/province [340]
0
0
Cheongju
Query!
Country [341]
0
0
Korea, Republic of
Query!
State/province [341]
0
0
Daegu
Query!
Country [342]
0
0
Korea, Republic of
Query!
State/province [342]
0
0
Daejeon
Query!
Country [343]
0
0
Korea, Republic of
Query!
State/province [343]
0
0
Gwangju
Query!
Country [344]
0
0
Korea, Republic of
Query!
State/province [344]
0
0
Jeonju
Query!
Country [345]
0
0
Korea, Republic of
Query!
State/province [345]
0
0
Seongnam-si
Query!
Country [346]
0
0
Korea, Republic of
Query!
State/province [346]
0
0
Seoul
Query!
Country [347]
0
0
Korea, Republic of
Query!
State/province [347]
0
0
Suwon-si
Query!
Country [348]
0
0
Korea, Republic of
Query!
State/province [348]
0
0
Uijeongbu
Query!
Country [349]
0
0
Korea, Republic of
Query!
State/province [349]
0
0
Wonju-si
Query!
Country [350]
0
0
Netherlands
Query!
State/province [350]
0
0
Almere
Query!
Country [351]
0
0
Netherlands
Query!
State/province [351]
0
0
Amersfoort
Query!
Country [352]
0
0
Netherlands
Query!
State/province [352]
0
0
Amsterdam
Query!
Country [353]
0
0
Netherlands
Query!
State/province [353]
0
0
Arnhem
Query!
Country [354]
0
0
Netherlands
Query!
State/province [354]
0
0
Beverwijk
Query!
Country [355]
0
0
Netherlands
Query!
State/province [355]
0
0
Breda
Query!
Country [356]
0
0
Netherlands
Query!
State/province [356]
0
0
Delft
Query!
Country [357]
0
0
Netherlands
Query!
State/province [357]
0
0
Den Haag
Query!
Country [358]
0
0
Netherlands
Query!
State/province [358]
0
0
Den Helder
Query!
Country [359]
0
0
Netherlands
Query!
State/province [359]
0
0
Deventer
Query!
Country [360]
0
0
Netherlands
Query!
State/province [360]
0
0
Drachten
Query!
Country [361]
0
0
Netherlands
Query!
State/province [361]
0
0
EDE
Query!
Country [362]
0
0
Netherlands
Query!
State/province [362]
0
0
Eindhoven
Query!
Country [363]
0
0
Netherlands
Query!
State/province [363]
0
0
Goes
Query!
Country [364]
0
0
Netherlands
Query!
State/province [364]
0
0
Groningen
Query!
Country [365]
0
0
Netherlands
Query!
State/province [365]
0
0
Hardenberg
Query!
Country [366]
0
0
Netherlands
Query!
State/province [366]
0
0
Heerenveen
Query!
Country [367]
0
0
Netherlands
Query!
State/province [367]
0
0
Heerlen
Query!
Country [368]
0
0
Netherlands
Query!
State/province [368]
0
0
Helmond
Query!
Country [369]
0
0
Netherlands
Query!
State/province [369]
0
0
Hilversum
Query!
Country [370]
0
0
Netherlands
Query!
State/province [370]
0
0
Hoofddorp
Query!
Country [371]
0
0
Netherlands
Query!
State/province [371]
0
0
Hoogeveen
Query!
Country [372]
0
0
Netherlands
Query!
State/province [372]
0
0
Leiderdorp
Query!
Country [373]
0
0
Netherlands
Query!
State/province [373]
0
0
Maastricht
Query!
Country [374]
0
0
Netherlands
Query!
State/province [374]
0
0
Nieuwegein
Query!
Country [375]
0
0
Netherlands
Query!
State/province [375]
0
0
Nijmegen
Query!
Country [376]
0
0
Netherlands
Query!
State/province [376]
0
0
OSS
Query!
Country [377]
0
0
Netherlands
Query!
State/province [377]
0
0
Roosendaal
Query!
Country [378]
0
0
Netherlands
Query!
State/province [378]
0
0
Rotterdam
Query!
Country [379]
0
0
Netherlands
Query!
State/province [379]
0
0
Schiedam
Query!
Country [380]
0
0
Netherlands
Query!
State/province [380]
0
0
Shertogenbosch
Query!
Country [381]
0
0
Netherlands
Query!
State/province [381]
0
0
Sittardgeleen
Query!
Country [382]
0
0
Netherlands
Query!
State/province [382]
0
0
Sneek
Query!
Country [383]
0
0
Netherlands
Query!
State/province [383]
0
0
Tiel
Query!
Country [384]
0
0
Netherlands
Query!
State/province [384]
0
0
Tilburg
Query!
Country [385]
0
0
Netherlands
Query!
State/province [385]
0
0
Veldhoven
Query!
Country [386]
0
0
Norway
Query!
State/province [386]
0
0
Bergen
Query!
Country [387]
0
0
Norway
Query!
State/province [387]
0
0
Bodo
Query!
Country [388]
0
0
Norway
Query!
State/province [388]
0
0
Bodø
Query!
Country [389]
0
0
Norway
Query!
State/province [389]
0
0
Flekkefjord
Query!
Country [390]
0
0
Norway
Query!
State/province [390]
0
0
Hamar
Query!
Country [391]
0
0
Norway
Query!
State/province [391]
0
0
Levanger
Query!
Country [392]
0
0
Norway
Query!
State/province [392]
0
0
Lillehammer
Query!
Country [393]
0
0
Norway
Query!
State/province [393]
0
0
Nesttun
Query!
Country [394]
0
0
Norway
Query!
State/province [394]
0
0
Oslo
Query!
Country [395]
0
0
Norway
Query!
State/province [395]
0
0
Skien
Query!
Country [396]
0
0
Norway
Query!
State/province [396]
0
0
Tromsø
Query!
Country [397]
0
0
Norway
Query!
State/province [397]
0
0
Tynset
Query!
Country [398]
0
0
Peru
Query!
State/province [398]
0
0
Arequipa
Query!
Country [399]
0
0
Peru
Query!
State/province [399]
0
0
Callao
Query!
Country [400]
0
0
Peru
Query!
State/province [400]
0
0
Lima
Query!
Country [401]
0
0
Peru
Query!
State/province [401]
0
0
San Borja
Query!
Country [402]
0
0
Peru
Query!
State/province [402]
0
0
Trujillo
Query!
Country [403]
0
0
Philippines
Query!
State/province [403]
0
0
Cebu City
Query!
Country [404]
0
0
Philippines
Query!
State/province [404]
0
0
Fuente Osmena Cebu City
Query!
Country [405]
0
0
Philippines
Query!
State/province [405]
0
0
Iloilo City
Query!
Country [406]
0
0
Philippines
Query!
State/province [406]
0
0
Las Pinas City
Query!
Country [407]
0
0
Philippines
Query!
State/province [407]
0
0
Lipa City
Query!
Country [408]
0
0
Philippines
Query!
State/province [408]
0
0
Mandaluyong City
Query!
Country [409]
0
0
Philippines
Query!
State/province [409]
0
0
Manila
Query!
Country [410]
0
0
Philippines
Query!
State/province [410]
0
0
Pasig City
Query!
Country [411]
0
0
Philippines
Query!
State/province [411]
0
0
Quezon City
Query!
Country [412]
0
0
Philippines
Query!
State/province [412]
0
0
Quezon
Query!
Country [413]
0
0
Philippines
Query!
State/province [413]
0
0
San Juan
Query!
Country [414]
0
0
Poland
Query!
State/province [414]
0
0
Bialystok
Query!
Country [415]
0
0
Poland
Query!
State/province [415]
0
0
Bielsko Biala
Query!
Country [416]
0
0
Poland
Query!
State/province [416]
0
0
Bydgoszcz
Query!
Country [417]
0
0
Poland
Query!
State/province [417]
0
0
Chorzow
Query!
Country [418]
0
0
Poland
Query!
State/province [418]
0
0
Gdansk
Query!
Country [419]
0
0
Poland
Query!
State/province [419]
0
0
Gdynia
Query!
Country [420]
0
0
Poland
Query!
State/province [420]
0
0
Gizycko
Query!
Country [421]
0
0
Poland
Query!
State/province [421]
0
0
Kraków
Query!
Country [422]
0
0
Poland
Query!
State/province [422]
0
0
Legnica
Query!
Country [423]
0
0
Poland
Query!
State/province [423]
0
0
Lubin
Query!
Country [424]
0
0
Poland
Query!
State/province [424]
0
0
Nowa Sól
Query!
Country [425]
0
0
Poland
Query!
State/province [425]
0
0
Olsztyn
Query!
Country [426]
0
0
Poland
Query!
State/province [426]
0
0
Opole
Query!
Country [427]
0
0
Poland
Query!
State/province [427]
0
0
Ostrów Mazowiecka
Query!
Country [428]
0
0
Poland
Query!
State/province [428]
0
0
Olawa
Query!
Country [429]
0
0
Poland
Query!
State/province [429]
0
0
Piotrkow
Query!
Country [430]
0
0
Poland
Query!
State/province [430]
0
0
Poznan
Query!
Country [431]
0
0
Poland
Query!
State/province [431]
0
0
Plock
Query!
Country [432]
0
0
Poland
Query!
State/province [432]
0
0
Skierniewice
Query!
Country [433]
0
0
Poland
Query!
State/province [433]
0
0
Sobótka
Query!
Country [434]
0
0
Poland
Query!
State/province [434]
0
0
Sokolka
Query!
Country [435]
0
0
Poland
Query!
State/province [435]
0
0
Szczecin
Query!
Country [436]
0
0
Poland
Query!
State/province [436]
0
0
Tarnów
Query!
Country [437]
0
0
Poland
Query!
State/province [437]
0
0
Torun
Query!
Country [438]
0
0
Poland
Query!
State/province [438]
0
0
Warszawa
Query!
Country [439]
0
0
Poland
Query!
State/province [439]
0
0
Wroclaw
Query!
Country [440]
0
0
Poland
Query!
State/province [440]
0
0
Wloclawek
Query!
Country [441]
0
0
Poland
Query!
State/province [441]
0
0
Lancut
Query!
Country [442]
0
0
Poland
Query!
State/province [442]
0
0
Lódz
Query!
Country [443]
0
0
Poland
Query!
State/province [443]
0
0
Leczna
Query!
Country [444]
0
0
Romania
Query!
State/province [444]
0
0
Bacau
Query!
Country [445]
0
0
Romania
Query!
State/province [445]
0
0
Braila
Query!
Country [446]
0
0
Romania
Query!
State/province [446]
0
0
Brasov
Query!
Country [447]
0
0
Romania
Query!
State/province [447]
0
0
Bucharest
Query!
Country [448]
0
0
Romania
Query!
State/province [448]
0
0
Bucuresti
Query!
Country [449]
0
0
Romania
Query!
State/province [449]
0
0
Buzau
Query!
Country [450]
0
0
Romania
Query!
State/province [450]
0
0
Cluj Napoca
Query!
Country [451]
0
0
Romania
Query!
State/province [451]
0
0
Craiova
Query!
Country [452]
0
0
Romania
Query!
State/province [452]
0
0
Deva
Query!
Country [453]
0
0
Romania
Query!
State/province [453]
0
0
Focsani
Query!
Country [454]
0
0
Romania
Query!
State/province [454]
0
0
Iasi
Query!
Country [455]
0
0
Romania
Query!
State/province [455]
0
0
Pitesti
Query!
Country [456]
0
0
Romania
Query!
State/province [456]
0
0
Sibiu
Query!
Country [457]
0
0
Romania
Query!
State/province [457]
0
0
Suceava
Query!
Country [458]
0
0
Romania
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Tg. Mures
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Romania
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Timisoara
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Russian Federation
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Moscow
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Russian Federation
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Perm
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Russian Federation
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Saint Petersburg
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Russian Federation
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Russian Federation
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St.-Petersburg
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Russian Federation
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Russian Federation
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StPetersburg
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Russian Federation
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Volgograd
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Martin
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George
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Parow
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Pretoria
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Worcester
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Spain
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Almeria
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Aviles
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Barcelona
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Bilbao
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Spain
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Don Benito (Badajoz)
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Spain
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Hospitalet de Llobregat(Barcel
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Spain
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Madrid
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Sweden
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Sweden
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Sweden
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Östersund
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Adana
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Turkey
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Istanbul
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Kharkiv
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Ukraine
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Kharkov
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Kiev
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Kyiv
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Antrim
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Blackpool
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Dundee
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East Kilbride
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Ely
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Hastings
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London
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Northampton
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Nottingham
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Peterborough
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Rotherham
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Sheffield
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Swansea
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Torquay
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York
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
AstraZeneca
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Address
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Ethics approval
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Summary
Brief summary
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
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Trial website
https://clinicaltrials.gov/study/NCT01225562
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Trial related presentations / publications
Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14. Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402. Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4. Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21. Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9. Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15. Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5. Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821. Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020. Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260. Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050. Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30. Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768. Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063. Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16. Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30. Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017. Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10. Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1. Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1. Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21. Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.
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