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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT01000727
Registration number
NCT01000727
Ethics application status
Date submitted
22/10/2009
Date registered
23/10/2009
Titles & IDs
Public title
The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial
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Scientific title
A Clinical Outcomes Study of Darapladib Versus Placebo in Subjects Following Acute Coronary Syndrome to Compare the Incidence of Major Adverse Cardiovascular Events (MACE).
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Secondary ID [1]
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480848/033
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Universal Trial Number (UTN)
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Trial acronym
SOLID-TIMI 52
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome
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Condition category
Condition code
Cardiovascular
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Coronary heart disease
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Other
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0
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Research that is not of generic health relevance and not applicable to specific health categories listed above
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Darapladib 160 mg
Treatment: Drugs - Placebo
Other interventions - Standard Therapy
Experimental: Darapladib 160 mg - Single daily oral tablet
Placebo comparator: Placebo - Single daily oral tablet
Treatment: Drugs: Darapladib 160 mg
Lp-PLA2 inhibitor
Treatment: Drugs: Placebo
Placebo administered
Other interventions: Standard Therapy
Guideline mandated therapy for individual's condition
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Intervention code [1]
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Treatment: Drugs
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Intervention code [2]
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Other interventions
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Number of Participants With First Occurrence of Any Event in the Composite of Major Coronary Events During the Time Period for Follow-up (FU) of Cardiovascular (CV) Event
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Assessment method [1]
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Coronary heart disease (CHD) death=occurrence of a fatal myocardial infarction (MI), death caused by documented cardiac arrest, death resulting from heart failure in a participant with known CHD, death from other forms of acute/chronic CHD, unwitnessed death of unknown origin, or sudden death. Acute MI=evidence of myocardial necrosis in a clinical setting consistent with myocardial ischemia. Prior MI diagnosed post-randomization (e.g., silent MI)=the development of new pathological Q waves with/without symptoms OR imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a nonischemic cause (pre-event imaging data required for verification of new abnormality), OR pathological findings of a healed/healing MI. Urgent coronary revascularization (CR) for MI=ischemic discomfort at rest that prompted CR during the same hospitalization or resulted in hospital transfer for the purpose of CR.
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Timepoint [1]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [1]
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Number of Participants With First Occurrence of Any Component of the Composite of Major Adverse Cardiovascular Events (Cardiovascular [CV] Death, Non-fatal MI or Non-fatal Stroke) During the Time Period for Follow-up of CV Events
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Assessment method [1]
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CV death=death due to a CV cause, which included but was not limited to deaths resulting from stroke, arrhythmia, sudden death (witnessed/unwitnessed), MI, heart failure, pulmonary embolism, peripheral arterial disease, or complications of a CV procedure. Deaths not clearly attributable to non-CV causes are considered to be CV deaths. Acute MI=evidence of myocardial necrosis in a clinical setting consistent with myocardial ischemia. Prior MI diagnosed post-randomization (e.g., silent MI)=the development of new pathological Q waves with/without symptoms OR imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a non-ischemic cause (pre-event imaging data required for verification of new abnormality), OR pathological findings of a healed/healing MI. Stroke=presence of a new focal neurologic deficit thought to be of vascular origin, with signs/symptoms lasting \>24 hours or results in death (in \<24 hours).
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Timepoint [1]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [2]
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Number of Participants With Cardiovascular Death During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [2]
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CV death is defined as a death due to a CV cause, which includes but is not limited to deaths resulting from stroke, arrhythmia, sudden death (witnessed/unwitnessed), MI, heart failure, pulmonary embolism, peripheral arterial disease, or complications of a CV procedure. Deaths not clearly attributable to non-CV causes are considered to be CV deaths.
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Timepoint [2]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [3]
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Number of Participants With First Occurrence of MI (Fatal/Nonfatal) During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [3]
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Acute MI is defined as evidence of myocardial necrosis in a clinical setting consistent with myocardial ischemia. Prior MI diagnosed post-randomization (e.g., silent MI)=the development of new pathological Q waves with/without symptoms OR imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a non-ischemic cause (pre-event imaging data required for verification of new abnormality), OR pathological findings of a healed/healing MI.
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Timepoint [3]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [4]
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Number of Participants With First Occurrence of Stroke (Fatal/Non-fatal) During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [4]
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Stroke is defined as the presence of a new focal neurologic deficit thought to be of vascular origin, with signs/symptoms lasting \>24 hours or results in death (in \<24 hours).
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Timepoint [4]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [5]
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Number of Participants With CHD Death During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [5]
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CHD death is defined as the occurrence of a fatal MI, death caused by documented cardiac arrest, death resulting from heart failure in a participant with known CHD, death from other forms of acute/chronic CHD, unwitnessed death of unknown origin, or sudden death.
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Timepoint [5]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [6]
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Number of Participants With Urgent Coronary Revascularization for Myocardial Ischemia During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [6]
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Urgent coronary revascularization for myocardial ischemia is defined as ischemic discomfort at rest that prompts coronary revascularization (PCI or coronary artery bypass graft \[CABG\]) during the same hospitalization or resulting in hospital transfer for the purpose of coronary revascularization. PCI is defined as any attempt at revascularization even if not successful (e.g., angioplasty, atherectomy or stenting).
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Timepoint [6]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [7]
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Number of Participants With First Occurrence of Any Event in the Composite of Total Coronary Events (CHD Death, Non-fatal MI, Hospitalization for Unstable Angina, or Any Coronary Revascularization Procedure) During the Time Period for FU of CV Events
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Assessment method [7]
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CHD death, acute MI, and prior MI diagnosed post-randomization are defined in the primary endpoint (major coronary events). Hospitalization for unstable angina=one of the following, but not fulfilling the criteria for MI: ischemic discomfort at rest associated with electrocardiogram (ECG) changes leading to hospitalization; ischemic discomfort at rest regardless of ECG changes leading to hospitalization and revascularization during the same admission; ischemic discomfort at rest in hospital associated with ECG changes; ischemic discomfort at rest in hospital without ECG changes resulting in revascularization during the same admission. NOTE: The event was not considered to be unstable angina if, after invasive/non-invasive testing or other diagnostic testing, the discomfort was found not to be caused by myocardial ischemia. Coronary revascularization procedures exclude PCI planned prior to randomization but performed after randomization.
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Timepoint [7]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [8]
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Number of Participants With First Occurrence of Any Coronary Revascularization Procedures (Excluding Coronary Revascularization Planned Prior to Randomization, But Performed After Randomization) During the Time Period for Follow-up of Cardiovascular Event
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Assessment method [8]
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All coronary revascularization procedures (except for PCI planned prior to randomization but performed after randomization) are included. Examples include coronary artery bypass graft, balloon angioplasty and stenting. The number of participants, with first occurrence of any coronary revascularization procedures, were reported.
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Timepoint [8]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [9]
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Number of Participants With First Occurrence of Any Component of the Composite of All-cause Mortality, Non-fatal MI, or Nonfatal Stroke During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [9]
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Acute MI is defined as evidence of myocardial necrosis in a clinical setting consistent with myocardial ischemia. Prior MI diagnosed post-randomization (e.g., silent MI)=the development of new pathological Q waves with/without symptoms OR imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a non-ischemic cause (pre-event imaging data required for verification of new abnormality), OR pathological findings of a healed/healing MI. Stroke=presence of a new focal neurologic deficit thought to be of vascular origin, with signs/symptoms lasting \>24 hours or results in death (in \<24 hours).
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Timepoint [9]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [10]
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Number of Participants With First Occurrence of Any Event in the Composite of CHD Death and Non-fatal MI During the Time Period for Follow-up of Cardiovascular Events
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Assessment method [10]
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Acute MI is defined as evidence of myocardial necrosis in a clinical setting consistent with myocardial ischemia. Prior MI diagnosed post-randomization (e.g., silent MI)=the development of new pathological Q waves with/without symptoms OR imaging evidence of a region of loss of viable myocardium that is thinned and fails to contract, in the absence of a non-ischemic cause (pre-event imaging data required for verification of new abnormality), OR pathological findings of a healed/healing MI. CHD death is defined as the occurrence of a fatal MI, death caused by documented cardiac arrest, death resulting from heart failure in a participant with known CHD, death from other forms of acute/chronic CHD, unwitnessed death of unknown origin, or sudden death.
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Timepoint [10]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Secondary outcome [11]
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Number of Participants With All-cause Mortality During the Time Period for Vital Status
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Assessment method [11]
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Number of participants who died, during the vital status time-period were reported. The participants who were known to have died, date of death was used; for participants who completed the study the study completion date was used; for participants who withdrew from the study where vital status was ascertained , and are known to have not died , the last known date to be alive was used and for participants whom vital status was not ascertained, following study withdrawal the study withdrawal date was used.
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Timepoint [11]
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From randomization until the End-of-Treatment visit or the last date on which endpoints were able to be assessed (up to 3.80 years)
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Eligibility
Key inclusion criteria
* Signed written informed consent.
* Men or women at least 18 years old (in Taiwan, at least 20 years old). Women must be post-menopausal or using a highly effective method for avoidance of pregnancy.
* Hospitalization for acute coronary syndrome (ACS) within 30 days prior to study entry.
* Clinically stable for 24 hours prior to study entry.
* A planned percutaneous coronary intervention (PCI) should be performed prior to study entry, whenever possible.
* At least one of the following:
* At least 60 years old.
* Myocardial infarction prior to the qualifying ACS event.
* Diabetes mellitus requiring treatment with medication.
* Diagnosed mild or moderate reduction in kidney function.
* Cerebrovascular disease (carotid artery disease or ischemic stroke more than 3 months prior to study entry) OR peripheral artery disease.
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* ACS symptoms or lab results not believed to be caused by a narrowing or blocked coronary artery.
* No major coronary artery with a blockage of more than 50% (unless all stenoses are successfully treated by PCI).
* Planned coronary artery bypass graft (CABG) surgery, or CABG surgery performed after the qualifying ACS event and prior to study entry.
* Certain types of liver disease.
* Severe reduction in kidney function OR removal of a kidney OR kidney transplant.
* Severe heart failure.
* Blood pressure higher than normal despite lifestyle changes and treatment with medications.
* Any life-threatening disease with a life expectancy of less than 2 years (other than heart disease) that may prevent the subject from completing the study.
* Severe asthma that is poorly controlled with medication.
* Pregnancy (Note: A pregnancy test will be performed on all non-sterile women prior to study entry).
* Previous severe allergic reaction to food, medications, drink, insect stings, etc.
* Drug or alcohol abuse within the past 6 months. Mental/psychological impairment that may prevent the subject from complying with study procedures or understanding the goal and potential risks of participating in the study.
* Certain medications that may interfere with the study medication (these will be identified by the study doctor).
* If both birth parents are at least 50% Japanese, Chinese, or Korean ancestry, must have a blood sample collected for Lp-PLA2 activity. Those with Lp-PLA2 activity less than or equal to 20.0 nmol/min/mL are excluded.
* Previously took darapladib (SB-480848).
* Participation in a study of an investigational medication within the past 30 days.
* Current participation in a study of an investigational device.
* Any other reason the investigator deems the subject should not participate in the study.
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Completed
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
1/12/2009
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
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Actual
24/04/2014
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Sample size
Target
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Accrual to date
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Final
13026
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,TAS,VIC,WA
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Recruitment hospital [1]
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GSK Investigational Site - Garran
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GSK Investigational Site - Camperdown
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GSK Investigational Site - Gosford
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GSK Investigational Site - Auchenflower
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GSK Investigational Site - Milton
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GSK Investigational Site - Elizabeth Vale
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GSK Investigational Site - Ashford
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Recruitment postcode(s) [1]
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2606 - Garran
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Recruitment postcode(s) [2]
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2050 - Camperdown
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2250 - Gosford
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4066 - Auchenflower
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4029 - Herston
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4064 - Milton
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Recruitment postcode(s) [7]
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5000 - Adelaide
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5112 - Elizabeth Vale
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7000 - Hobart
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3128 - Box Hill
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6009 - Nedlands
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6160 - Fremantle
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Recruitment postcode(s) [13]
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5035 - Ashford
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Recruitment outside Australia
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Santa fe
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Zárate
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0
Belgium
Query!
State/province [61]
0
0
Leuven
Query!
Country [62]
0
0
Belgium
Query!
State/province [62]
0
0
Liège
Query!
Country [63]
0
0
Belgium
Query!
State/province [63]
0
0
Roeselaere
Query!
Country [64]
0
0
Brazil
Query!
State/province [64]
0
0
Bahía
Query!
Country [65]
0
0
Brazil
Query!
State/province [65]
0
0
Ceará
Query!
Country [66]
0
0
Brazil
Query!
State/province [66]
0
0
Goiás
Query!
Country [67]
0
0
Brazil
Query!
State/province [67]
0
0
Minas Gerais
Query!
Country [68]
0
0
Brazil
Query!
State/province [68]
0
0
Paraná
Query!
Country [69]
0
0
Brazil
Query!
State/province [69]
0
0
Rio Grande Do Sul
Query!
Country [70]
0
0
Brazil
Query!
State/province [70]
0
0
Rio Grande Du Norte
Query!
Country [71]
0
0
Brazil
Query!
State/province [71]
0
0
São Paulo
Query!
Country [72]
0
0
Brazil
Query!
State/province [72]
0
0
Bahia
Query!
Country [73]
0
0
Brazil
Query!
State/province [73]
0
0
Brasília
Query!
Country [74]
0
0
Brazil
Query!
State/province [74]
0
0
Campinas
Query!
Country [75]
0
0
Brazil
Query!
State/province [75]
0
0
Campo Grande
Query!
Country [76]
0
0
Brazil
Query!
State/province [76]
0
0
Rio de Janeiro
Query!
Country [77]
0
0
Brazil
Query!
State/province [77]
0
0
Rio De Janeiro
Query!
Country [78]
0
0
Brazil
Query!
State/province [78]
0
0
São Paulo - SP
Query!
Country [79]
0
0
Brazil
Query!
State/province [79]
0
0
Uberlandia
Query!
Country [80]
0
0
Bulgaria
Query!
State/province [80]
0
0
Dimitrovgrad
Query!
Country [81]
0
0
Bulgaria
Query!
State/province [81]
0
0
Haskovo
Query!
Country [82]
0
0
Bulgaria
Query!
State/province [82]
0
0
Pleven
Query!
Country [83]
0
0
Bulgaria
Query!
State/province [83]
0
0
Plovdiv
Query!
Country [84]
0
0
Bulgaria
Query!
State/province [84]
0
0
Sofia
Query!
Country [85]
0
0
Bulgaria
Query!
State/province [85]
0
0
Veliko Tarnovo
Query!
Country [86]
0
0
Canada
Query!
State/province [86]
0
0
Alberta
Query!
Country [87]
0
0
Canada
Query!
State/province [87]
0
0
British Columbia
Query!
Country [88]
0
0
Canada
Query!
State/province [88]
0
0
Newfoundland and Labrador
Query!
Country [89]
0
0
Canada
Query!
State/province [89]
0
0
Nova Scotia
Query!
Country [90]
0
0
Canada
Query!
State/province [90]
0
0
Ontario
Query!
Country [91]
0
0
Canada
Query!
State/province [91]
0
0
Quebec
Query!
Country [92]
0
0
Chile
Query!
State/province [92]
0
0
Región De La Araucania
Query!
Country [93]
0
0
Chile
Query!
State/province [93]
0
0
Región Del Biobio
Query!
Country [94]
0
0
Chile
Query!
State/province [94]
0
0
Región Metro De Santiago
Query!
Country [95]
0
0
Chile
Query!
State/province [95]
0
0
Valparaíso
Query!
Country [96]
0
0
Chile
Query!
State/province [96]
0
0
Santiago
Query!
Country [97]
0
0
Chile
Query!
State/province [97]
0
0
Temuco
Query!
Country [98]
0
0
China
Query!
State/province [98]
0
0
Gansu
Query!
Country [99]
0
0
China
Query!
State/province [99]
0
0
Guangdong
Query!
Country [100]
0
0
China
Query!
State/province [100]
0
0
Guangxi
Query!
Country [101]
0
0
China
Query!
State/province [101]
0
0
Hainan
Query!
Country [102]
0
0
China
Query!
State/province [102]
0
0
Hebei
Query!
Country [103]
0
0
China
Query!
State/province [103]
0
0
Jiangsu
Query!
Country [104]
0
0
China
Query!
State/province [104]
0
0
Liaoning
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Shaanxi
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Shandong
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Sichuan
Query!
Country [108]
0
0
China
Query!
State/province [108]
0
0
Zhejiang
Query!
Country [109]
0
0
China
Query!
State/province [109]
0
0
Beijing
Query!
Country [110]
0
0
China
Query!
State/province [110]
0
0
Hangzhou
Query!
Country [111]
0
0
China
Query!
State/province [111]
0
0
Jinan
Query!
Country [112]
0
0
China
Query!
State/province [112]
0
0
Shanghai
Query!
Country [113]
0
0
China
Query!
State/province [113]
0
0
Suzhou
Query!
Country [114]
0
0
Colombia
Query!
State/province [114]
0
0
Armenia
Query!
Country [115]
0
0
Colombia
Query!
State/province [115]
0
0
Barranquilla
Query!
Country [116]
0
0
Colombia
Query!
State/province [116]
0
0
Bogota
Query!
Country [117]
0
0
Colombia
Query!
State/province [117]
0
0
Bogotá
Query!
Country [118]
0
0
Colombia
Query!
State/province [118]
0
0
Bucaramanga
Query!
Country [119]
0
0
Colombia
Query!
State/province [119]
0
0
Cartagena
Query!
Country [120]
0
0
Colombia
Query!
State/province [120]
0
0
Manizales
Query!
Country [121]
0
0
Colombia
Query!
State/province [121]
0
0
Medellin
Query!
Country [122]
0
0
Colombia
Query!
State/province [122]
0
0
Medellín
Query!
Country [123]
0
0
Czechia
Query!
State/province [123]
0
0
Brno
Query!
Country [124]
0
0
Czechia
Query!
State/province [124]
0
0
Caslav
Query!
Country [125]
0
0
Czechia
Query!
State/province [125]
0
0
Jihlava
Query!
Country [126]
0
0
Czechia
Query!
State/province [126]
0
0
Kromeriz
Query!
Country [127]
0
0
Czechia
Query!
State/province [127]
0
0
Milevsko
Query!
Country [128]
0
0
Czechia
Query!
State/province [128]
0
0
Olomouc
Query!
Country [129]
0
0
Czechia
Query!
State/province [129]
0
0
Plzen - Bory
Query!
Country [130]
0
0
Czechia
Query!
State/province [130]
0
0
Praha 10
Query!
Country [131]
0
0
Czechia
Query!
State/province [131]
0
0
Praha 2
Query!
Country [132]
0
0
Czechia
Query!
State/province [132]
0
0
Slany
Query!
Country [133]
0
0
Czechia
Query!
State/province [133]
0
0
Svitavy
Query!
Country [134]
0
0
Czechia
Query!
State/province [134]
0
0
Usti nad Orlici
Query!
Country [135]
0
0
Czechia
Query!
State/province [135]
0
0
Zlin
Query!
Country [136]
0
0
Denmark
Query!
State/province [136]
0
0
Aalborg
Query!
Country [137]
0
0
Denmark
Query!
State/province [137]
0
0
Aarhus
Query!
Country [138]
0
0
Denmark
Query!
State/province [138]
0
0
Esbjerg
Query!
Country [139]
0
0
Denmark
Query!
State/province [139]
0
0
Frederikssund
Query!
Country [140]
0
0
Denmark
Query!
State/province [140]
0
0
Glostrup
Query!
Country [141]
0
0
Denmark
Query!
State/province [141]
0
0
Hellerup
Query!
Country [142]
0
0
Denmark
Query!
State/province [142]
0
0
Herlev
Query!
Country [143]
0
0
Denmark
Query!
State/province [143]
0
0
Holbæk
Query!
Country [144]
0
0
Denmark
Query!
State/province [144]
0
0
Hvidovre
Query!
Country [145]
0
0
Denmark
Query!
State/province [145]
0
0
Koebenhavn N
Query!
Country [146]
0
0
Denmark
Query!
State/province [146]
0
0
Kolding
Query!
Country [147]
0
0
Denmark
Query!
State/province [147]
0
0
København NV
Query!
Country [148]
0
0
Denmark
Query!
State/province [148]
0
0
København S
Query!
Country [149]
0
0
Denmark
Query!
State/province [149]
0
0
Køge
Query!
Country [150]
0
0
Denmark
Query!
State/province [150]
0
0
Næstved
Query!
Country [151]
0
0
Denmark
Query!
State/province [151]
0
0
Odense C
Query!
Country [152]
0
0
Denmark
Query!
State/province [152]
0
0
Roskilde
Query!
Country [153]
0
0
Denmark
Query!
State/province [153]
0
0
Silkeborg
Query!
Country [154]
0
0
Denmark
Query!
State/province [154]
0
0
Svendborg
Query!
Country [155]
0
0
France
Query!
State/province [155]
0
0
Aquitaine
Query!
Country [156]
0
0
France
Query!
State/province [156]
0
0
Champagne-Ardenne
Query!
Country [157]
0
0
France
Query!
State/province [157]
0
0
Nord-Pas-de-Calais
Query!
Country [158]
0
0
France
Query!
State/province [158]
0
0
Avignon
Query!
Country [159]
0
0
France
Query!
State/province [159]
0
0
Besançon Cedex
Query!
Country [160]
0
0
France
Query!
State/province [160]
0
0
Bron
Query!
Country [161]
0
0
France
Query!
State/province [161]
0
0
Créteil
Query!
Country [162]
0
0
France
Query!
State/province [162]
0
0
Dijon Cedex
Query!
Country [163]
0
0
France
Query!
State/province [163]
0
0
Lagny sur Marne
Query!
Country [164]
0
0
France
Query!
State/province [164]
0
0
Le Plessis Robinson
Query!
Country [165]
0
0
France
Query!
State/province [165]
0
0
Lille
Query!
Country [166]
0
0
France
Query!
State/province [166]
0
0
Marseille Cedex 08
Query!
Country [167]
0
0
France
Query!
State/province [167]
0
0
Montfermeil
Query!
Country [168]
0
0
France
Query!
State/province [168]
0
0
Paris Cedex 18
Query!
Country [169]
0
0
France
Query!
State/province [169]
0
0
Paris
Query!
Country [170]
0
0
France
Query!
State/province [170]
0
0
Poitiers
Query!
Country [171]
0
0
France
Query!
State/province [171]
0
0
Quincy sous Sénart
Query!
Country [172]
0
0
France
Query!
State/province [172]
0
0
Rennes
Query!
Country [173]
0
0
France
Query!
State/province [173]
0
0
Strasbourg Cedex
Query!
Country [174]
0
0
France
Query!
State/province [174]
0
0
Toulouse
Query!
Country [175]
0
0
France
Query!
State/province [175]
0
0
Tourcoing
Query!
Country [176]
0
0
France
Query!
State/province [176]
0
0
Valenciennes
Query!
Country [177]
0
0
Germany
Query!
State/province [177]
0
0
Baden-Wuerttemberg
Query!
Country [178]
0
0
Germany
Query!
State/province [178]
0
0
Bayern
Query!
Country [179]
0
0
Germany
Query!
State/province [179]
0
0
Hessen
Query!
Country [180]
0
0
Germany
Query!
State/province [180]
0
0
Niedersachsen
Query!
Country [181]
0
0
Germany
Query!
State/province [181]
0
0
Nordrhein-Westfalen
Query!
Country [182]
0
0
Germany
Query!
State/province [182]
0
0
Rheinland-Pfalz
Query!
Country [183]
0
0
Germany
Query!
State/province [183]
0
0
Saarland
Query!
Country [184]
0
0
Germany
Query!
State/province [184]
0
0
Schleswig-Holstein
Query!
Country [185]
0
0
Germany
Query!
State/province [185]
0
0
Thueringen
Query!
Country [186]
0
0
Germany
Query!
State/province [186]
0
0
Berlin
Query!
Country [187]
0
0
Germany
Query!
State/province [187]
0
0
Bremen
Query!
Country [188]
0
0
Germany
Query!
State/province [188]
0
0
Halle
Query!
Country [189]
0
0
Germany
Query!
State/province [189]
0
0
Hamburg
Query!
Country [190]
0
0
Hungary
Query!
State/province [190]
0
0
Budapest
Query!
Country [191]
0
0
Hungary
Query!
State/province [191]
0
0
Cegléd
Query!
Country [192]
0
0
Hungary
Query!
State/province [192]
0
0
Eger
Query!
Country [193]
0
0
Hungary
Query!
State/province [193]
0
0
Gyula
Query!
Country [194]
0
0
Hungary
Query!
State/province [194]
0
0
Hodmezovasarhely
Query!
Country [195]
0
0
Hungary
Query!
State/province [195]
0
0
Kistarcsa
Query!
Country [196]
0
0
Hungary
Query!
State/province [196]
0
0
Miskolc
Query!
Country [197]
0
0
Hungary
Query!
State/province [197]
0
0
Szolnok
Query!
Country [198]
0
0
Hungary
Query!
State/province [198]
0
0
Szombathely
Query!
Country [199]
0
0
Hungary
Query!
State/province [199]
0
0
Székesfehérvár
Query!
Country [200]
0
0
Hungary
Query!
State/province [200]
0
0
Zalaegerszeg
Query!
Country [201]
0
0
India
Query!
State/province [201]
0
0
Ahmedabad
Query!
Country [202]
0
0
India
Query!
State/province [202]
0
0
Amritsar
Query!
Country [203]
0
0
India
Query!
State/province [203]
0
0
Chennai
Query!
Country [204]
0
0
India
Query!
State/province [204]
0
0
Faridabad
Query!
Country [205]
0
0
India
Query!
State/province [205]
0
0
Gandhinagar
Query!
Country [206]
0
0
India
Query!
State/province [206]
0
0
Gurgaon
Query!
Country [207]
0
0
India
Query!
State/province [207]
0
0
Hyderabad
Query!
Country [208]
0
0
India
Query!
State/province [208]
0
0
Indore
Query!
Country [209]
0
0
India
Query!
State/province [209]
0
0
Jaipur
Query!
Country [210]
0
0
India
Query!
State/province [210]
0
0
Lucknow
Query!
Country [211]
0
0
India
Query!
State/province [211]
0
0
Mohali
Query!
Country [212]
0
0
India
Query!
State/province [212]
0
0
New Delhi
Query!
Country [213]
0
0
India
Query!
State/province [213]
0
0
Noida
Query!
Country [214]
0
0
India
Query!
State/province [214]
0
0
Patiala
Query!
Country [215]
0
0
India
Query!
State/province [215]
0
0
Pune,
Query!
Country [216]
0
0
India
Query!
State/province [216]
0
0
Pune
Query!
Country [217]
0
0
India
Query!
State/province [217]
0
0
Secunderabad,
Query!
Country [218]
0
0
India
Query!
State/province [218]
0
0
Vadodara
Query!
Country [219]
0
0
India
Query!
State/province [219]
0
0
Visakhapatnam
Query!
Country [220]
0
0
Israel
Query!
State/province [220]
0
0
Ashkelon
Query!
Country [221]
0
0
Israel
Query!
State/province [221]
0
0
Beer Sheva
Query!
Country [222]
0
0
Israel
Query!
State/province [222]
0
0
Haddera
Query!
Country [223]
0
0
Israel
Query!
State/province [223]
0
0
Haifa
Query!
Country [224]
0
0
Israel
Query!
State/province [224]
0
0
Holon
Query!
Country [225]
0
0
Israel
Query!
State/province [225]
0
0
Jerusalem
Query!
Country [226]
0
0
Israel
Query!
State/province [226]
0
0
Kfar Saba
Query!
Country [227]
0
0
Israel
Query!
State/province [227]
0
0
Nahariya
Query!
Country [228]
0
0
Israel
Query!
State/province [228]
0
0
Poriya
Query!
Country [229]
0
0
Israel
Query!
State/province [229]
0
0
Raanana
Query!
Country [230]
0
0
Israel
Query!
State/province [230]
0
0
Ramat-Gan
Query!
Country [231]
0
0
Israel
Query!
State/province [231]
0
0
Rehovot
Query!
Country [232]
0
0
Israel
Query!
State/province [232]
0
0
Safed
Query!
Country [233]
0
0
Israel
Query!
State/province [233]
0
0
Tel Aviv
Query!
Country [234]
0
0
Italy
Query!
State/province [234]
0
0
Calabria
Query!
Country [235]
0
0
Italy
Query!
State/province [235]
0
0
Campania
Query!
Country [236]
0
0
Italy
Query!
State/province [236]
0
0
Emilia-Romagna
Query!
Country [237]
0
0
Italy
Query!
State/province [237]
0
0
Friuli-Venezia-Giulia
Query!
Country [238]
0
0
Italy
Query!
State/province [238]
0
0
Lazio
Query!
Country [239]
0
0
Italy
Query!
State/province [239]
0
0
Lombardia
Query!
Country [240]
0
0
Italy
Query!
State/province [240]
0
0
Marche
Query!
Country [241]
0
0
Italy
Query!
State/province [241]
0
0
Piemonte
Query!
Country [242]
0
0
Italy
Query!
State/province [242]
0
0
Sardegna
Query!
Country [243]
0
0
Italy
Query!
State/province [243]
0
0
Toscana
Query!
Country [244]
0
0
Italy
Query!
State/province [244]
0
0
Veneto
Query!
Country [245]
0
0
Italy
Query!
State/province [245]
0
0
Legnano
Query!
Country [246]
0
0
Italy
Query!
State/province [246]
0
0
Sassuolo
Query!
Country [247]
0
0
Japan
Query!
State/province [247]
0
0
Chiba
Query!
Country [248]
0
0
Japan
Query!
State/province [248]
0
0
Fukuoka
Query!
Country [249]
0
0
Japan
Query!
State/province [249]
0
0
Hokkaido
Query!
Country [250]
0
0
Japan
Query!
State/province [250]
0
0
Hyogo
Query!
Country [251]
0
0
Japan
Query!
State/province [251]
0
0
Kanagawa
Query!
Country [252]
0
0
Japan
Query!
State/province [252]
0
0
Kyoto
Query!
Country [253]
0
0
Japan
Query!
State/province [253]
0
0
Nagasaki
Query!
Country [254]
0
0
Japan
Query!
State/province [254]
0
0
Oita
Query!
Country [255]
0
0
Japan
Query!
State/province [255]
0
0
Okayama
Query!
Country [256]
0
0
Japan
Query!
State/province [256]
0
0
Osaka
Query!
Country [257]
0
0
Japan
Query!
State/province [257]
0
0
Saga
Query!
Country [258]
0
0
Japan
Query!
State/province [258]
0
0
Shizuoka
Query!
Country [259]
0
0
Japan
Query!
State/province [259]
0
0
Tokyo
Query!
Country [260]
0
0
Korea, Republic of
Query!
State/province [260]
0
0
Dae-Gu
Query!
Country [261]
0
0
Korea, Republic of
Query!
State/province [261]
0
0
Daejeon
Query!
Country [262]
0
0
Korea, Republic of
Query!
State/province [262]
0
0
Gangnam-gu, Seoul
Query!
Country [263]
0
0
Korea, Republic of
Query!
State/province [263]
0
0
Gwangju
Query!
Country [264]
0
0
Korea, Republic of
Query!
State/province [264]
0
0
Kangwon-do
Query!
Country [265]
0
0
Korea, Republic of
Query!
State/province [265]
0
0
Pusan
Query!
Country [266]
0
0
Korea, Republic of
Query!
State/province [266]
0
0
Seoul
Query!
Country [267]
0
0
Netherlands
Query!
State/province [267]
0
0
's-Hertogenbosch
Query!
Country [268]
0
0
Netherlands
Query!
State/province [268]
0
0
Amersfoort
Query!
Country [269]
0
0
Netherlands
Query!
State/province [269]
0
0
Amsterdam
Query!
Country [270]
0
0
Netherlands
Query!
State/province [270]
0
0
Apeldoorn
Query!
Country [271]
0
0
Netherlands
Query!
State/province [271]
0
0
Blaricum
Query!
Country [272]
0
0
Netherlands
Query!
State/province [272]
0
0
Den Haag
Query!
Country [273]
0
0
Netherlands
Query!
State/province [273]
0
0
Deventer
Query!
Country [274]
0
0
Netherlands
Query!
State/province [274]
0
0
Dirksland
Query!
Country [275]
0
0
Netherlands
Query!
State/province [275]
0
0
Doetinchem
Query!
Country [276]
0
0
Netherlands
Query!
State/province [276]
0
0
Drachten
Query!
Country [277]
0
0
Netherlands
Query!
State/province [277]
0
0
Eindhoven
Query!
Country [278]
0
0
Netherlands
Query!
State/province [278]
0
0
Gorinchem
Query!
Country [279]
0
0
Netherlands
Query!
State/province [279]
0
0
Gouda
Query!
Country [280]
0
0
Netherlands
Query!
State/province [280]
0
0
Groningen
Query!
Country [281]
0
0
Netherlands
Query!
State/province [281]
0
0
Hardenberg
Query!
Country [282]
0
0
Netherlands
Query!
State/province [282]
0
0
Harderwijk
Query!
Country [283]
0
0
Netherlands
Query!
State/province [283]
0
0
Heerenveen
Query!
Country [284]
0
0
Netherlands
Query!
State/province [284]
0
0
Heerlen
Query!
Country [285]
0
0
Netherlands
Query!
State/province [285]
0
0
Helmond
Query!
Country [286]
0
0
Netherlands
Query!
State/province [286]
0
0
Hilversum
Query!
Country [287]
0
0
Netherlands
Query!
State/province [287]
0
0
Hoofddorp
Query!
Country [288]
0
0
Netherlands
Query!
State/province [288]
0
0
Hoorn
Query!
Country [289]
0
0
Netherlands
Query!
State/province [289]
0
0
Nijmegen
Query!
Country [290]
0
0
Netherlands
Query!
State/province [290]
0
0
OSS
Query!
Country [291]
0
0
Netherlands
Query!
State/province [291]
0
0
Roermond
Query!
Country [292]
0
0
Netherlands
Query!
State/province [292]
0
0
Rotterdam
Query!
Country [293]
0
0
Netherlands
Query!
State/province [293]
0
0
Sittard-geleen
Query!
Country [294]
0
0
Netherlands
Query!
State/province [294]
0
0
Sneek
Query!
Country [295]
0
0
Netherlands
Query!
State/province [295]
0
0
Tiel
Query!
Country [296]
0
0
Netherlands
Query!
State/province [296]
0
0
Tilburg
Query!
Country [297]
0
0
Netherlands
Query!
State/province [297]
0
0
Veldhoven
Query!
Country [298]
0
0
Netherlands
Query!
State/province [298]
0
0
Venlo
Query!
Country [299]
0
0
Netherlands
Query!
State/province [299]
0
0
Zoetermeer
Query!
Country [300]
0
0
New Zealand
Query!
State/province [300]
0
0
Auckland
Query!
Country [301]
0
0
New Zealand
Query!
State/province [301]
0
0
Christchurch
Query!
Country [302]
0
0
New Zealand
Query!
State/province [302]
0
0
Dunedin
Query!
Country [303]
0
0
New Zealand
Query!
State/province [303]
0
0
Hamilton
Query!
Country [304]
0
0
New Zealand
Query!
State/province [304]
0
0
Lower Hutt
Query!
Country [305]
0
0
New Zealand
Query!
State/province [305]
0
0
New Plymouth
Query!
Country [306]
0
0
New Zealand
Query!
State/province [306]
0
0
Palmerston North
Query!
Country [307]
0
0
New Zealand
Query!
State/province [307]
0
0
Takapuna, Auckland
Query!
Country [308]
0
0
New Zealand
Query!
State/province [308]
0
0
Tauranga
Query!
Country [309]
0
0
New Zealand
Query!
State/province [309]
0
0
Whangarei
Query!
Country [310]
0
0
Peru
Query!
State/province [310]
0
0
Lima
Query!
Country [311]
0
0
Peru
Query!
State/province [311]
0
0
Callao
Query!
Country [312]
0
0
Peru
Query!
State/province [312]
0
0
Lima Cercado
Query!
Country [313]
0
0
Philippines
Query!
State/province [313]
0
0
Cebu City
Query!
Country [314]
0
0
Philippines
Query!
State/province [314]
0
0
Davao
Query!
Country [315]
0
0
Philippines
Query!
State/province [315]
0
0
Manila
Query!
Country [316]
0
0
Philippines
Query!
State/province [316]
0
0
Quezon City
Query!
Country [317]
0
0
Poland
Query!
State/province [317]
0
0
Bialystok
Query!
Country [318]
0
0
Poland
Query!
State/province [318]
0
0
Bydgoszcz
Query!
Country [319]
0
0
Poland
Query!
State/province [319]
0
0
Bytom
Query!
Country [320]
0
0
Poland
Query!
State/province [320]
0
0
Chrzanow
Query!
Country [321]
0
0
Poland
Query!
State/province [321]
0
0
Gdansk
Query!
Country [322]
0
0
Poland
Query!
State/province [322]
0
0
Gdynia
Query!
Country [323]
0
0
Poland
Query!
State/province [323]
0
0
Inowroclaw
Query!
Country [324]
0
0
Poland
Query!
State/province [324]
0
0
Krakow
Query!
Country [325]
0
0
Poland
Query!
State/province [325]
0
0
Lodz
Query!
Country [326]
0
0
Poland
Query!
State/province [326]
0
0
Lubin
Query!
Country [327]
0
0
Poland
Query!
State/province [327]
0
0
Mielec
Query!
Country [328]
0
0
Poland
Query!
State/province [328]
0
0
Olawa
Query!
Country [329]
0
0
Poland
Query!
State/province [329]
0
0
Opole
Query!
Country [330]
0
0
Poland
Query!
State/province [330]
0
0
Radom
Query!
Country [331]
0
0
Poland
Query!
State/province [331]
0
0
Skierniewice
Query!
Country [332]
0
0
Poland
Query!
State/province [332]
0
0
Tarnow
Query!
Country [333]
0
0
Poland
Query!
State/province [333]
0
0
Torun
Query!
Country [334]
0
0
Poland
Query!
State/province [334]
0
0
Tychy
Query!
Country [335]
0
0
Poland
Query!
State/province [335]
0
0
Walbrzych
Query!
Country [336]
0
0
Poland
Query!
State/province [336]
0
0
Warsaw
Query!
Country [337]
0
0
Poland
Query!
State/province [337]
0
0
Warszawa
Query!
Country [338]
0
0
Poland
Query!
State/province [338]
0
0
Wloclawek
Query!
Country [339]
0
0
Poland
Query!
State/province [339]
0
0
Wroclaw
Query!
Country [340]
0
0
Poland
Query!
State/province [340]
0
0
Zamosc
Query!
Country [341]
0
0
Poland
Query!
State/province [341]
0
0
Zielona Gora
Query!
Country [342]
0
0
Romania
Query!
State/province [342]
0
0
Baia Mare
Query!
Country [343]
0
0
Romania
Query!
State/province [343]
0
0
Braila
Query!
Country [344]
0
0
Romania
Query!
State/province [344]
0
0
Brasov
Query!
Country [345]
0
0
Romania
Query!
State/province [345]
0
0
Bucharest
Query!
Country [346]
0
0
Romania
Query!
State/province [346]
0
0
Cluj-Napoca
Query!
Country [347]
0
0
Romania
Query!
State/province [347]
0
0
Constanta
Query!
Country [348]
0
0
Romania
Query!
State/province [348]
0
0
Craiova
Query!
Country [349]
0
0
Romania
Query!
State/province [349]
0
0
Iasi
Query!
Country [350]
0
0
Romania
Query!
State/province [350]
0
0
Targu Mures
Query!
Country [351]
0
0
Russian Federation
Query!
State/province [351]
0
0
Barnaul
Query!
Country [352]
0
0
Russian Federation
Query!
State/province [352]
0
0
Ekaterinburg
Query!
Country [353]
0
0
Russian Federation
Query!
State/province [353]
0
0
Gatchina
Query!
Country [354]
0
0
Russian Federation
Query!
State/province [354]
0
0
Kemerovo
Query!
Country [355]
0
0
Russian Federation
Query!
State/province [355]
0
0
Krasnoyarsk
Query!
Country [356]
0
0
Russian Federation
Query!
State/province [356]
0
0
Moscow
Query!
Country [357]
0
0
Russian Federation
Query!
State/province [357]
0
0
Nizhniy Novgorod
Query!
Country [358]
0
0
Russian Federation
Query!
State/province [358]
0
0
Novosibirsk
Query!
Country [359]
0
0
Russian Federation
Query!
State/province [359]
0
0
Orenburg
Query!
Country [360]
0
0
Russian Federation
Query!
State/province [360]
0
0
Samara
Query!
Country [361]
0
0
Russian Federation
Query!
State/province [361]
0
0
Saratov
Query!
Country [362]
0
0
Russian Federation
Query!
State/province [362]
0
0
St'Petersburg
Query!
Country [363]
0
0
Russian Federation
Query!
State/province [363]
0
0
St-Petersburg
Query!
Country [364]
0
0
Russian Federation
Query!
State/province [364]
0
0
St. Petersburg
Query!
Country [365]
0
0
Russian Federation
Query!
State/province [365]
0
0
Tomsk
Query!
Country [366]
0
0
Russian Federation
Query!
State/province [366]
0
0
Tyumen
Query!
Country [367]
0
0
Russian Federation
Query!
State/province [367]
0
0
Yaroslavl
Query!
Country [368]
0
0
Slovakia
Query!
State/province [368]
0
0
Bratislava
Query!
Country [369]
0
0
Slovakia
Query!
State/province [369]
0
0
Kosice
Query!
Country [370]
0
0
Slovakia
Query!
State/province [370]
0
0
Nitra
Query!
Country [371]
0
0
Slovakia
Query!
State/province [371]
0
0
Nove Zamky
Query!
Country [372]
0
0
South Africa
Query!
State/province [372]
0
0
Free State
Query!
Country [373]
0
0
South Africa
Query!
State/province [373]
0
0
Gauteng
Query!
Country [374]
0
0
South Africa
Query!
State/province [374]
0
0
KwaZulu- Natal
Query!
Country [375]
0
0
South Africa
Query!
State/province [375]
0
0
Western Province
Query!
Country [376]
0
0
South Africa
Query!
State/province [376]
0
0
Goodwood
Query!
Country [377]
0
0
South Africa
Query!
State/province [377]
0
0
Kempton Park
Query!
Country [378]
0
0
South Africa
Query!
State/province [378]
0
0
Paarl
Query!
Country [379]
0
0
South Africa
Query!
State/province [379]
0
0
Parktown West
Query!
Country [380]
0
0
South Africa
Query!
State/province [380]
0
0
Parow
Query!
Country [381]
0
0
South Africa
Query!
State/province [381]
0
0
Pretoria
Query!
Country [382]
0
0
South Africa
Query!
State/province [382]
0
0
Somerset West
Query!
Country [383]
0
0
South Africa
Query!
State/province [383]
0
0
Worcester
Query!
Country [384]
0
0
Spain
Query!
State/province [384]
0
0
Alicante
Query!
Country [385]
0
0
Spain
Query!
State/province [385]
0
0
Barcelona
Query!
Country [386]
0
0
Spain
Query!
State/province [386]
0
0
Lerida
Query!
Country [387]
0
0
Spain
Query!
State/province [387]
0
0
León
Query!
Country [388]
0
0
Spain
Query!
State/province [388]
0
0
Madrid
Query!
Country [389]
0
0
Spain
Query!
State/province [389]
0
0
Malaga
Query!
Country [390]
0
0
Spain
Query!
State/province [390]
0
0
Oviedo
Query!
Country [391]
0
0
Spain
Query!
State/province [391]
0
0
San Juan/Alicante
Query!
Country [392]
0
0
Spain
Query!
State/province [392]
0
0
San Sebastián de los Reyes/Madrid
Query!
Country [393]
0
0
Spain
Query!
State/province [393]
0
0
San Sebastián
Query!
Country [394]
0
0
Spain
Query!
State/province [394]
0
0
Sevilla
Query!
Country [395]
0
0
Spain
Query!
State/province [395]
0
0
Valencia
Query!
Country [396]
0
0
Spain
Query!
State/province [396]
0
0
Vigo/Pontevedra
Query!
Country [397]
0
0
Sweden
Query!
State/province [397]
0
0
Göteborg
Query!
Country [398]
0
0
Sweden
Query!
State/province [398]
0
0
Hässleholm
Query!
Country [399]
0
0
Sweden
Query!
State/province [399]
0
0
Jönköping
Query!
Country [400]
0
0
Sweden
Query!
State/province [400]
0
0
Stockholm
Query!
Country [401]
0
0
Sweden
Query!
State/province [401]
0
0
Västerås
Query!
Country [402]
0
0
Sweden
Query!
State/province [402]
0
0
Örebro
Query!
Country [403]
0
0
Sweden
Query!
State/province [403]
0
0
Östersund
Query!
Country [404]
0
0
Taiwan
Query!
State/province [404]
0
0
Kaohsiung City
Query!
Country [405]
0
0
Taiwan
Query!
State/province [405]
0
0
Kaohsiung
Query!
Country [406]
0
0
Taiwan
Query!
State/province [406]
0
0
Taipei
Query!
Country [407]
0
0
Taiwan
Query!
State/province [407]
0
0
Yung Kang City
Query!
Country [408]
0
0
Thailand
Query!
State/province [408]
0
0
Bangkoknoi
Query!
Country [409]
0
0
Thailand
Query!
State/province [409]
0
0
Bangkok
Query!
Country [410]
0
0
Thailand
Query!
State/province [410]
0
0
Chiangmai
Query!
Country [411]
0
0
Thailand
Query!
State/province [411]
0
0
Khon Kaen, Muang
Query!
Country [412]
0
0
Thailand
Query!
State/province [412]
0
0
Nakhon Ratchasima
Query!
Country [413]
0
0
Thailand
Query!
State/province [413]
0
0
Pathumthani
Query!
Country [414]
0
0
Turkey
Query!
State/province [414]
0
0
Ankara
Query!
Country [415]
0
0
Turkey
Query!
State/province [415]
0
0
Erzurum
Query!
Country [416]
0
0
Turkey
Query!
State/province [416]
0
0
Eskisehir
Query!
Country [417]
0
0
Turkey
Query!
State/province [417]
0
0
Izmir
Query!
Country [418]
0
0
Ukraine
Query!
State/province [418]
0
0
Dnipropetrovsk
Query!
Country [419]
0
0
Ukraine
Query!
State/province [419]
0
0
Donetsk
Query!
Country [420]
0
0
Ukraine
Query!
State/province [420]
0
0
Kharkiv
Query!
Country [421]
0
0
Ukraine
Query!
State/province [421]
0
0
Kyiv
Query!
Country [422]
0
0
Ukraine
Query!
State/province [422]
0
0
Lugansk
Query!
Country [423]
0
0
Ukraine
Query!
State/province [423]
0
0
Lutsk
Query!
Country [424]
0
0
Ukraine
Query!
State/province [424]
0
0
Mykolaiv
Query!
Country [425]
0
0
Ukraine
Query!
State/province [425]
0
0
Odesa
Query!
Country [426]
0
0
Ukraine
Query!
State/province [426]
0
0
Simferopol
Query!
Country [427]
0
0
Ukraine
Query!
State/province [427]
0
0
Vinnytsia
Query!
Country [428]
0
0
Ukraine
Query!
State/province [428]
0
0
Zaporizhzhya
Query!
Country [429]
0
0
United Kingdom
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Devon
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Lanarkshire
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Middlesex
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Northamptonshire
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Nottinghamshire
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Surrey
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West Midlands
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Antrim
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Chichester
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East Kilbride
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Hertfordshire
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Liverpool
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Paisley
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United Kingdom
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Stirling
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
GlaxoSmithKline
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Other collaborator category [1]
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Other
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The TIMI Study Group
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Ethics approval
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Summary
Brief summary
This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or urgent coronary revascularization (e.g. medical procedures performed to restore the normal blood flow in patients with atherosclerosis)) when treatment is started within 30 days after an acute coronary syndrome (also called ACS).
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Trial website
https://clinicaltrials.gov/study/NCT01000727
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Trial related presentations / publications
Correa S, Morrow DA, Braunwald E, Davies RY, Goodrich EL, Murphy SA, Cannon CP, O'Donoghue ML. Cystatin C for Risk Stratification in Patients After an Acute Coronary Syndrome. J Am Heart Assoc. 2018 Oct 16;7(20):e009077. doi: 10.1161/JAHA.118.009077. Barger LK, Rajaratnam SMW, Cannon CP, Lukas MA, Im K, Goodrich EL, Czeisler CA, O'Donoghue ML. Short Sleep Duration, Obstructive Sleep Apnea, Shiftwork, and the Risk of Adverse Cardiovascular Events in Patients After an Acute Coronary Syndrome. J Am Heart Assoc. 2017 Oct 10;6(10):e006959. doi: 10.1161/JAHA.117.006959. Eisen A, Cannon CP, Braunwald E, Steen DL, Zhou J, Goodrich EL, Im K, Dalby AJ, Spinar J, Daga S, Lukas MA, O'Donoghue ML. Predictors of Nonuse of a High-Potency Statin After an Acute Coronary Syndrome: Insights From the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) Trial. J Am Heart Assoc. 2017 Jan 11;6(1):e004332. doi: 10.1161/JAHA.116.004332. O'Donoghue ML, Braunwald E, White HD, Lukas MA, Tarka E, Steg PG, Hochman JS, Bode C, Maggioni AP, Im K, Shannon JB, Davies RY, Murphy SA, Crugnale SE, Wiviott SD, Bonaca MP, Watson DF, Weaver WD, Serruys PW, Cannon CP; SOLID-TIMI 52 Investigators; Steen DL. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. JAMA. 2014 Sep 10;312(10):1006-15. doi: 10.1001/jama.2014.11061. Erratum In: JAMA. 2014 Oct 8;312(14):1473. Dylan P. Steen[corrected to Dylan L. Steen]. O'Donoghue ML, Braunwald E, White HD, Serruys P, Steg PG, Hochman J, Maggioni AP, Bode C, Weaver D, Johnson JL, Cicconetti G, Lukas MA, Tarka E, Cannon CP. Study design and rationale for the Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome. Am Heart J. 2011 Oct;162(4):613-619.e1. doi: 10.1016/j.ahj.2011.07.018. Epub 2011 Sep 15.
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Public notes
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Contacts
Principal investigator
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GSK Clinical Trials
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GlaxoSmithKline
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Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
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What data in particular will be shared?
Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.
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When will data be available (start and end dates)?
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Available to whom?
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Available for what types of analyses?
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How or where can data be obtained?
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What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results are available at
https://clinicaltrials.gov/study/NCT01000727